D048

MPP⁺ iodide

≥98% (HPLC), ERα antagonist, powder

• Sinónimos: 1-Methyl-4-phenylpyridinium iodide
• Fórmula empírica (notación de Hill): C₁₂H₁₂IN
• Número CAS: 36913-39-0
• Peso molecular: 297.13
• UNSPSC Code: 12352200
• PubChem Substance ID: 24893235
• NACRES: NA.77
• MDL number: MFCD00055096
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Nombre del producto: MPP⁺ iodide, ≥98% (HPLC), powder
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 10 mg/mL, clear
• SMILES string: [I-].C[n+]1ccc(cc1)-c2ccccc2
• InChI: 1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1
• InChI key: RFDFRDXIIKROAI-UHFFFAOYSA-M

Descripción

General description

1-Methyl-4-phenylpyridinium (MPP+) acts as a selective ERα antagonist.induces neurotoxicity by inhibiting mitochondrial redox functions in the striatal synaptosomes. It is a potential neurotoxin and induces Parkinson′s disease in animal models. It mediates apoptosis by the generation of reactive oxygen species in cerebellar granule neurons and neuroblastoma cells. MPP+ modulates the distribution of dopamine. It elicits neurotoxicity by activating neuronal nitric oxide synthase (nNOS), resulting in excess nitric oxide.

Application

MPP+ iodide has been used:

• to induce oxidative stress in zebrafish embryos
• for the inhibition of glutamate uptake in mitochondria of astrocytes
• in testing cell viability using MTT (3 (4,5-dimethylthiazol)-2-yl-2,5-diphenyltetrazolium bromide) in microglia (BV2) cells

Biochem/physiol Actions

Active metabolite of dopaminergic neurotoxin MPTP

MPP⁺ iodide is an active metabolite of dopaminergic neurotoxin MPTP.

Preparation Note

Solutions should be freshly prepared.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Photosensitive.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331,H315,H319,H335
• pcodes: P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges