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Merck

C9819

Sigma-Aldrich

Chondroitin sulfate A sodium salt from bovine trachea

lyophilized powder, BioReagent, suitable for cell culture

Sinónimos:

Alternating Copoly β-glucuronic acid-(1→3)-N-acetyl-β-galactosamine-4-sulfate-(1→4)

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About This Item

Número de CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.75
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

bovine trachea

Nivel de calidad

Línea del producto

BioReagent

Formulario

lyophilized powder

envase

poly bottle of 25 g
poly bottle of 5 g

técnicas

cell culture | mammalian: suitable

cobertura de la superficie

20‑2000 μg/cm2

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

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Aplicación

Chondroitin appears to play a regulatory role for chondrocytes, neural cells, and some tumor cells. Chondroitin sulfate B is used to study ß peptide (1-42) cytotoxicity.

Acciones bioquímicas o fisiológicas

As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.

Componentes

Chondroitin Sulfate A is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, D-glucuronic acid, and sulfate residues in equimolar quantities where carbon 4 of the N-acetylgalactosamines is sulfated.

Precaución

Store this product at 2-8°C.

Nota de preparación

This product is soluble in water at 100 mg/mL.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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N Sharma et al.
Osteoarthritis and cartilage, 28(5), 658-668 (2019-11-18)
Links between pain and joint degradation are poorly understood. We investigated the role of activation of Toll-like receptors (TLR) by cartilage metabolites in initiating and maintaining the inflammatory loop in OA causing joint destruction. Synovial membrane explants (SMEs) were prepared
Jingsong Wang et al.
Scientific reports, 10(1), 21658-21658 (2020-12-12)
Meniscus degeneration is closely related to the progression of knee osteoarthritis (OA). However, there is currently a lack of quantitative and objective metrics to assess OA meniscal cell phenotypes. In this study we investigated the phenotypic markers and chondrogenic potency
Philippe Boeuf et al.
PloS one, 6(6), e21126-e21126 (2011-07-07)
In placental malaria, Plasmodium falciparum-infected erythrocytes adhere to the apical plasma membrane of the placental epithelium, triggering an impairment of placental function detrimental to the fetus. The design of anti-adhesion intervention strategies requires a detailed understanding of the mechanisms involved.
Dovile Sinkeviciute et al.
BMC rheumatology, 4, 30-30 (2020-05-20)
Osteoarthritis (OA) is a progressive, chronic disease characterized by articular cartilage destruction. The pro-inflammatory cytokine IL-17 levels have been reported elevated in serum and synovial fluid of OA patients and correlated with increased cartilage defects and bone remodeling. The aim
Gunnar Dick et al.
The Journal of biological chemistry, 288(38), 27384-27395 (2013-08-14)
Chondroitin sulfate (CS) and the CS-rich extracellular matrix structures called perineuronal nets (PNNs) restrict plasticity and regeneration in the CNS. Plasticity is enhanced by chondroitinase ABC treatment that removes CS from its core protein in the chondroitin sulfate proteoglycans or

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Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

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Questions

  1. What is the molecular weight of this Chondroitin sulfate A

    1 answer
    1. The molecular weight of CSA is variable and not determined for this product. However, the average values from historical records and literature sources are in the range of 20-30 kDa.

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