C8895

Clofazimine

≥98% (TLC), powder, antimycobacterial rimonphenazine

• Sinónimos: N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine
• Fórmula empírica (notación de Hill): C₂₇H₂₂Cl₂N₄
• Número de CAS: 2030-63-9
• Peso molecular: 473.40
• Número CE: 217-980-2
• Número MDL: MFCD00056793
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24893114
• NACRES: NA.77

Propiedades

• Nombre del producto: Clofazimine,
• Formulario: powder
• Nivel de calidad: 200
• espectro de actividad antibiótica: mycobacteria
• Modo de acción: protein synthesis | interferes
• emisor: Novartis
• cadena SMILES: CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5
• InChI: 1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+
• Clave InChI: WDQPAMHFFCXSNU-BGABXYSRSA-N

Descripción

Descripción general

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Aplicación

Clofazimine has been used:

• for antimicrobial preparation
• to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
• to model drug-induced hepatic granulomatous inflammation
• to study the in vivo cargo storage capacity of macrophages

Características y beneficios

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Almacenamiento y estabilidad

This product is stored at room temperature.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves