C6013

Cholesteryl hemisuccinate tris salt

anionic detergent

• Sinónimos: 3β-Hydroxy-5-cholestene 3-hemisuccinate, 5-Cholesten-3β-ol 3-hemisuccinate, CHEMS, CHS, Cholesteryl hydrogen succinate
• Fórmula empírica (notación de Hill): C₃₁H₅₀O₄ · C₄H₁₁NO₃
• Número de CAS: 102601-49-0
• Peso molecular: 607.86
• Número MDL: MFCD00058298
• Código UNSPSC: 12352211
• eCl@ss: 39023139
• ID de la sustancia en PubChem: 329775108
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• Nivel de calidad: 200
• Ensayo: ≥98% (TLC)
• Formulario: powder
• grupo funcional: ester
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: NC(CO)(CO)CO.CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
• InChI: 1S/C31H50O4.C4H11NO3/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5;5-4(1-6,2-7)3-8/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33);6-8H,1-3,5H2/t21-,23+,24+,25-,26+,27+,30+,31-;/m1./s1
• Clave InChI: SLDYONDUXRBLLR-XTCKSVDZSA-N

Descripción

Aplicación

Cholesteryl hemisuccinate tris salt has been used:

• to prepare solubilization buffer for glucan synthase assay
• to prepare immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads.
• as a membrane stabilizer for liposomes and protein synaptogyrin-1
• as a component of a folate-modified self-microemulsifying drug delivery system.
• with N-dodecyl β-D-maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1
• for protein solubilization

Acciones bioquímicas o fisiológicas

Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.

Nota de preparación

Cholesteryl hemisuccinate tris salt yields clear, colorless solution in methanol at 10 mg/ml.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable