B7431

Bryostatin 1

≥99%, solid

• Sinónimos: NSC 339555
• Fórmula empírica (notación de Hill): C₄₇H₆₈O₁₇
• Número de CAS: 83314-01-6
• Peso molecular: 905.03
• Número MDL: MFCD00893832
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24891991
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥99%
• Formulario: solid
• color: white
• solubilidad: DMSO: soluble; ethanol: soluble
• temp. de almacenamiento: −20°C
• cadena SMILES: [H]\C(C(=O)OC)=C1/C[C@@]2([H])C[C@]3(O)O[C@]([H])(C[C@@H](O)CC(=O)O[C@H](C[C@]4([H])C\C(=C(\[H])C(=O)OC)[C@H](OC(=O)\C=C\C=C\CCC)[C@@](O)(O4)C(C)(C)\C=C\[C@@]([H])(C1)O2)[C@@H](C)O)C[C@H](OC(C)=O)C3(C)C
• InChI: 1S/C47H68O17/c1-10-11-12-13-14-15-39(51)62-43-31(22-41(53)58-9)21-34-25-37(28(2)48)61-42(54)24-32(50)23-35-26-38(59-29(3)49)45(6,7)46(55,63-35)27-36-19-30(20-40(52)57-8)18-33(60-36)16-17-44(4,5)47(43,56)64-34/h12-17,20,22,28,32-38,43,48,50,55-56H,10-11,18-19,21,23-27H2,1-9H3/b13-12+,15-14+,17-16+,30-20+,31-22+/t28-,32-,33+,34+,35-,36+,37-,38+,43+,46+,47-/m1/s1
• Clave InChI: MJQUEDHRCUIRLF-TVIXENOKSA-N

Descripción

Aplicación

Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in mice.[1] It has also been used to study its effects as an anthelmintic drug on adult Syphacia muris infection in rats.[2]

Acciones bioquímicas o fisiológicas

Bryostatin 1 (Bry1) is a macrocyclic lactone.[3] This synaptogenic compound[4] is obtained from the marine bryozoan Bugula neritina.[1] Bry1 is capable of reversing synaptic loss. It can enable synaptic maturation in animal models with several neurological disorders.[3] It possesses antidepressant activity, when administered intracebroventricularly.[4] Bry1 is known to participate in protecting cell tight junctions (TJs), anti-inflammatory functions and immune regulation.[1]

Macrolactone isolated from the marine bryozoan Bugula neritina that initially activates and subsequently down-regulates protein kinase C (PKC). More potent than phorbol myristate acetate for translocating PKCδ and ε.

Otras notas

Binds to glass and plastic in aqueous solutions

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)