This product is constructed with a single deletion of Asp from the N-terminus to create a hypoallergenic construct. Structural equivalence to native albumin is confirmed by x-ray crystallography. The Asp deletion eliminates an important antigenic determinant by removing the principal copper and nickel binding site of albumin. The first three residues of human albumin are considered non-structural. Additionally, the product is blocked at Cys34 to improve stability, monomer content, and homogeneity.
A7736
Albúmina human
recombinant, expressed in Pichia pastoris, lyophilized powder, ≥90% (agarose gel electrophoresis)
Sinónimos:
rHSA
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About This Item
Fórmula empírica (notación de Hill):
C2936H4624N786O889S41
Número de CAS:
Peso molecular:
66471.53
EC Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.25
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
biological source
human
Quality Level
recombinant
expressed in Pichia pastoris
assay
≥90% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer ~67 kDa
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Gene Information
human ... ALB(213)
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Application
Esta variante recombinante se recomienda para investigación en absorción, distribución, metabolismo y excreción (ADME) farmacológica; cultivo celular; investigación de administración de medicamentos; y crioconservación de las células.
Biochem/physiol Actions
Las albúminas son proteínas monómeras solubles que se encuentran en los líquidos y los tejidos de los animales y en algunas semillas vegetales. La seroalbúmina funciona como proteína transportadora para esteroides, ácidos grasos y hormonas tiroideas. Las seroalbúminas son también vitales en la regulación de las presiones osmóticas coloidales de la sangre.
Physical properties
Construct with a single deletion of Asp from the N-terminus to create a hypoallergenic construct. Structural equivalence to native albumin confirmed x-ray crystallography. The Asp deletion eliminates an important antigenic determinant by eliminating the principal copper and nickel binding site of albumin. The first three residues of human albumin are considered non-structural. Also blocked at Cys34 to improve stability, monomer content and homogeneity.
Other Notes
Encontrará más información en seroalbúmina humana.
Legal Information
Albagen is a trademark of Albumin Therapeutics, LLC.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Hi there, I am looking at the product A7736 recombinant human albumin and I see it is "Albagen™ synonym" according to the description. I know that Albagen has a single deletion N-terminus. So it is not 100% HSA. what about A7736?
1 answer-
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