A4352
Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-phospho-AMPA Glutamate Receptor 1 (pSer831)
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 100 kDa
reactividad de especies
rat, human
concentración
~1 mg/mL
técnicas
direct ELISA: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1:1,000 using rat brain (hippocampal) homogenate
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
phosphorylation (pSer831)
Información sobre el gen
human ... GRIA1(2890)
rat ... Gria1(50592)
Descripción general
AMPA is a transmembrane receptor for glutamate that regulates synapsis in the central nervous system. It is composed of 4 types of subunits, GluR1, 2, 3, 4.
GluR1 subunits of AMPA receptors are membrane proteins that regulate synaptic plasticity of the central nervous system. This receptor has also been implicated in spatial memory retention. Phosphorylation of serine 831 in GluR1 subunit of the AMPA receptor modulates long-term potentiation in neuronal synapses. Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is specific for the GluR1 subunit (phosphorylated on serine 831) of the AMPA receptor in rats and humans.
Inmunógeno
The GluR1 sequence is conserved among species and has partial homology to VGLUT2.
synthetic phosphopeptide corresponding to a region near serine 831 of rat glutamate receptor subunit GluR1.
Aplicación
Anti-phospho-AMPA Receptor, GluR1 Subunit (pSer831) antibody is suitable for use in direct ELISA, immunohistochemistry, immunoblot and immunoprecipitation. The antibody may also be used for western blot (1:1,000 using rat hippocampal homogenate).
Forma física
Solution in 10 mM HEPES buffer, pH 7.5, containing 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Hey-Kyoung Lee et al.
Journal of neurophysiology, 103(1), 479-489 (2009-11-13)
Activity-dependent changes in excitatory synaptic transmission in the CNS have been shown to depend on the regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs). In particular, several lines of evidence suggest that reversible phosphorylation of AMPAR subunit glutamate receptor 1 (GluR1
Hey-Kyoung Lee et al.
Cell, 112(5), 631-643 (2003-03-12)
Plasticity of the nervous system is dependent on mechanisms that regulate the strength of synaptic transmission. Excitatory synapses in the brain undergo long-term potentiation (LTP) and long-term depression (LTD), cellular models of learning and memory. Protein phosphorylation is required for
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