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Merck

47612

Sigma-Aldrich

Folinic acid calcium salt hydrate

BioXtra, ≥99.0% (HPLC)

Sinónimos:

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

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About This Item

Fórmula empírica (notación de Hill):
C20H21CaN7O7 · xH2O
Número de CAS:
Peso molecular:
511.50 (anhydrous basis)
Beilstein:
5723924
Número MDL:
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
NACRES:
NA.28
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

synthetic

Nivel de calidad

Línea del producto

BioXtra

Ensayo

≥99.0% (HPLC)

Formulario

powder or crystals

técnicas

cell culture | mammalian: suitable

color

white to faint yellow

mp

240-250 °C

aplicaciones

cell analysis

cadena SMILES

[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

InChI

1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1

Clave InChI

KVUAALJSMIVURS-ZEDZUCNESA-L

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Descripción general

Calcium salt of the (6R,S)-mixture of diastereomers of 5-formyl-5,6,7,8-tetrahydrofolate.
Folinic acid, also called as calcium leucovorin, is usually available as an amorphous powder and lacks odor.[1] This activated form of vitamin B9[2] is off-white to light beige in color.[1] Folic acid (FA) is a water-soluble vitamin. Folinic acid is the 5-formyl derivative of tetrahydrofolic acid and is the reduced form of folic acid.[3]

Aplicación

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Folinic acid calcium salt hydrate has been used in the preparation of topical 1% and 2.5% folinic acid creams for use in wound healing studies.[4] It has also been used as a component in the chemically defined-Chinese hamster ovary medium (CD-CHO) to culture CHO DUKX B11.[5]

Acciones bioquímicas o fisiológicas

Folinic acid serves as a cofactor and participates in one-carbon-transfer reactions.[2] It helps in improving wound healing in rats.[4] Folinic acid plays a major role in children with autism to enhance verbal communication.[6]

Otras notas

Review[7]

Pictogramas

Health hazardExclamation mark

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificados de análisis (COA)

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Visite la Librería de documentos

L.O. Pont et al.
Anal. Profiles Drug Subst., 8, 315-315 (1979)
Nutritional Regulation of Mitochondrial Function
Mitochondria, 93-126 (2019)
Methotrexate-induced cytotoxicity and genotoxicity in germ cells of mice: Intervention of folic and folinic acid
Padmanabhan S, et al.
Mutation Research, 673(1), 43-52 (2009)
Topical folinic acid enhances wound healing in rat model
Duman N, et al.
Advances in Medical Sciences, 63(2), 347-352 (2018)
Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial
Frye RE, et al.
Molecular Psychiatry, 23, 247-247 (2018)

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Chromatograms

application for HPLCapplication for HPLC

Questions

1–2 of 2 Questions  
  1. What is this soluble in, and what is the solubility? No info online or with product. No lot number indicated on vial. Really lacking info here.

    1 answer
    1. Solubility testing is not performed on this product. However, F7878 Folinic acid calcium salt hydrate is soluble in water at 100 mg/mL. These are identical compounds of different brands, with the same physical properties.

      Please see the link below to review this product specification sheet:
      https://www.sigmaaldrich.com/specification-sheets/189/322/F7878-BULK________SIAL_____.pdf

      Helpful?

  2. What is the storage temperature for this product?

    1 answer
    1. This product can be stored in room temperature.

      Helpful?

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