Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
44583
Doxorrubicina hydrochloride
suitable for fluorescence, 98.0-102.0% (HPLC)
Sinónimos:
DOX, Hidroxidaunorrubicina hydrochloride
About This Item
Productos recomendados
origen biológico
synthetic
Nivel de calidad
Ensayo
98.0-102.0% (HPLC)
Formulario
solid
color
orange to dark red
mp
216 °C (dec.) (lit.)
solubilidad
H2O: 50 mg/mL, clear, orange to red
DMSO: soluble
THF: soluble
ethanol: soluble
methanol: soluble
fluorescencia
λem 580-590 nm
idoneidad
suitable for fluorescence
espectro de actividad antibiótica
neoplastics
Modo de acción
DNA synthesis | interferes
enzyme | inhibits
temp. de almacenamiento
2-8°C
cadena SMILES
Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Clave InChI
MWWSFMDVAYGXBV-RUELKSSGSA-N
Información sobre el gen
human ... TOP2A(7153)
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Descripción general
Aplicación
Acciones bioquímicas o fisiológicas
Envase
Otras notas
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Certificados de análisis (COA)
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Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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Doxorubicin (44583) can dissolve in PBS only or not?
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Yes, this product is soluble in water at 50 mg/mL. PBS and other aqueous buffers would also be an option.
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How should I use Product D1515 - Doxorubicin hydrochloride to induce double strand breaks in the DNA of HeLa cells?
1 answer-
We do not test Product D1515 - Doxorubicin hydrochloride for biological activity with HELA cells. The following paper used 100 nM to 250 nM doxorubicin Adam Hermawan, et al., Journal of Natural Remedies, Vol. 12/2 (2012) 108-114The following paper uses 0.01 to 1.0 mug/ml doxorubicin SH Kim, et al., CANCER RESEARCH 32, 323-325, February 1972
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How stable is a solution of Doxorubicin hydrochloride, Product 44583?
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According to the 11th edition of the chemicals encyclopedia published by the Royal Society of Chemistry, "aqueous solutions are unchanged after one month at 5 °C but unstable at higher temperatures or at either acid or alkaline pH. Several studies cite that stability is related to pH, exposure to light and the medium used for storage. Doxorubicin hydrochloride is subject to light degradation at °C in the dark in 5% glucose, pH 4.7 (or 3.3% glucose + 0.3% sodium chloride, pH 4.4), solutions were stable (5% or less change) for at least 4 weeks".
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the function of Doxorubicin hydrochloride, Product 44583?
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In chemotherapy: "Doxorubicin HCl is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin." -National Cancer Institute.
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At what concentration can Doxorubicin hydrochloride, Product 44583, be dissolved in water? At what concentration in DMSO?
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The solubility of Product No. 44583 tested in water (50 mg/mL), yielding a clear orange to red solution. It is also soluble in DMSO (50 mg/mL), ethanol, methanol and tetrahydrofuran.
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