369A-1

Phosphohistone H3 (PHH3) Rabbit Polyclonal Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100; 500
• conjugado: unconjugated
• forma del anticuerpo: Ig fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• descripción: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Formulario: buffered aqueous solution
• reactividad de especies: human
• envase: vial of 0.1 mL concentrate (369A-14); vial of 0.5 mL concentrate (369A-15); bottle of 1.0 mL predilute (369A-17); vial of 1.0 mL concentrate (369A-16); bottle of 7.0 mL predilute (369A-18)
• fabricante / nombre comercial: Cell Marque^®
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• control: tonsil
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• visualización: nuclear
• Información sobre el gen: human ... H3C1(8350)

Descripción

Descripción general

Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis. Therefore, PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in the diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.

Calidad

IVD

IVD

IVD

RUO

Ligadura / enlace

Phosphohistone H3 (PHH3) Positive Control Slides, Product No. 369S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany