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Merck

Y0000412

Sulfamethoxazole impurity A

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

N4-Acetylsulfamethoxazole, N-Acetyl sulfamethoxazole, Acetyl-sulfamethoxazole, N-{4-{[(5-Methyl-3-isoxazolyl)amino]sulfonyl}phenyl}acetamide, Sulfisomezole-N4-acetate

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About This Item

Fórmula empírica (notación de Hill):
C12H13N3O4S
Número de CAS:
Peso molecular:
295.31
Beilstein:
285801
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

sulfamethoxazole

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O=S(NC1=NOC(C)=C1)(C2=CC=C(NC(C)=O)C=C2)=O

InChI

1S/C12H13N3O4S/c1-8-7-12(14-19-8)15-20(17,18)11-5-3-10(4-6-11)13-9(2)16/h3-7H,1-2H3,(H,13,16)(H,14,15)

Clave InChI

GXPIUNZCALHVBA-UHFFFAOYSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Sulfamethoxazole impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Lot/Batch Number

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R C Stevens et al.
Antimicrobial agents and chemotherapy, 37(3), 448-452 (1993-03-01)
The disposition of 12 mg of trimethoprim and 60 mg of sulfamethoxazole per kg of body weight in six healthy male volunteers is described. The daily dose was evenly divided and administered orally every 6 h for 13 consecutive doses.
T B Vree et al.
Journal of veterinary pharmacology and therapeutics, 6(1), 77-81 (1983-03-01)
Sulphamethoxazole and its metabolite, N4-acetylsulphamethoxazole, were shown to cross the placenta of a pregnant ewe. The plasma concentration of N4-acetylsulphamethoxazole increased in the foetus due to the limited elimination properties of the immature kidney. The amniotic fluid concentration of sulphamethoxazole
Significance of apparent half-lives of a metabolite with a higher elimination rate than its parent drug.
T B Vree et al.
Drug intelligence & clinical pharmacy, 16(2), 126-131 (1982-02-01)
Acetylation of sulphamethoxazole by the snail Cepaea hortensis.
T B Vree et al.
Journal of veterinary pharmacology and therapeutics, 7(3), 239-241 (1984-09-01)
R Gochin et al.
Journal of chromatography, 223(1), 139-145 (1981-04-10)
The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetyl-sulphamethoxazole in serum and urine by high-performance liquid chromatography using sulphafurazole as internal standard is described. The separation was achieved on a reversed-phase column employing acetic acid-methanol as the mobile phase with spectrophotometric

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