PHR1338

Triclosan

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: Triclosan, 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Irgasan
• Fórmula empírica (notación de Hill): C₁₂H₇Cl₃O₂
• Número de CAS: 3380-34-5
• Peso molecular: 289.54
• Beilstein: 2057142
• Número CE: 222-182-2
• Número MDL: MFCD00800992
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823323
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to USP 1682206
• familia API: triclosan
• CofA: current certificate can be downloaded
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl
• InChI: 1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
• Clave InChI: XEFQLINVKFYRCS-UHFFFAOYSA-N

Descripción

Descripción general

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Triclosan is a non-ionic broad spectrum antibacterial and antifungal agent, used in personal care products such as antiseptic soaps, toothpastes, fabrics and plastics.

Aplicación

A component of cefsulodin-irgasan-novobiocin selection medium for Yersinia, a human pathogen that may contaminate animal-source food products.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Triclosan may be used as a pharmaceutical reference standard for the determination of the analyte in waste water samples and food stuffs by various chromatography methods.

Acciones bioquímicas o fisiológicas

It is an inhibitor of the enoyl-ACP (acyl-carrier protein) reductase component of type II fatty acid synthase (FAS-II) in bacteria and Plasmodium. It also inhibits mammalian fatty acid synthase (FASN), and may have anticarcinogenic activity.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA9502 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H410
• Consejos de prudencia: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable