PHR1026

Ranitidine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Sinónimos: N, N Dimethyl-5-[2-(1-methylamine-2-nitrovinyl)-ethylthiomethyl]furfurylamine hydrochloride
• Fórmula empírica (notación de Hill): C₁₃H₂₂N₄O₃S · HCl
• Número de CAS: 66357-59-3
• Peso molecular: 350.86
• Número CE: 266-333-0
• Número MDL: MFCD00069339
• Código UNSPSC: 41116107
• ID de la sustancia en PubChem: 329823056
• NACRES: NA.24

Propiedades

• grado: certified reference material; pharmaceutical secondary standard
• Nivel de calidad: 300
• Agency: traceable to BP 471; traceable to Ph. Eur. R0150000; traceable to USP 1598405
• familia API: ranitidine
• CofA: current certificate can be downloaded
• técnicas: HPLC: suitable; gas chromatography (GC): suitable
• aplicaciones: pharmaceutical (small molecule)
• Formato: neat
• temp. de almacenamiento: 2-30°C
• cadena SMILES: Cl[H].CN\C(NCCSCc1ccc(CN(C)C)o1)=C\[N+]([O-])=O
• InChI: 1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H/b13-9-;
• Clave InChI: GGWBHVILAJZWKJ-CHHCPSLASA-N

Descripción

Descripción general

Ranitidine hydrochloride is a H₂-receptor antagonist, widely used for the management of hypersecretory conditions and for the treatment of duodenal ulcer.[1]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

Ranitidine hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using titrimetry and visible spectrophotometry techniques.[2]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Acciones bioquímicas o fisiológicas

H2 histamine receptor antagonist; anti-ulcer agent.

H₂ histamine receptor antagonist; anti-ulcer agent.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAA5630 in the slot below. This is an example certificate only and may not be the lot that you receive.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H315,H317,H319,H334,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable