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P0310000

Penicillamine

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

D-Penicillamine, 3,3-Dimethyl-D-cysteine, 3-Mercapto-D-valine, D-(−)-2-Amino-3-mercapto-3-methylbutanoic acid

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About This Item

Fórmula lineal:
(CH3)2C(SH)CH(NH2)CO2H
Número de CAS:
52-67-5
Peso molecular:
149.21
Beilstein:
1722375
Número MDL:
MFCD00064302
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329820030
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

penicillamine

fabricante / nombre comercial

EDQM

mp

210 °C (dec.) (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

CC(C)(S)[C@@H](N)C(O)=O

InChI

1S/C5H11NO2S/c1-5(2,9)3(6)4(7)8/h3,9H,6H2,1-2H3,(H,7,8)/t3-/m0/s1

Clave InChI

VVNCNSJFMMFHPL-VKHMYHEASA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Penicillamine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Warning

Frases de peligro

H361d

Clasificaciones de peligro

Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

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Certificados de análisis (COA)

Lot/Batch Number

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Rim Ishak et al.
American journal of clinical dermatology, 14(3), 223-233 (2013-04-23)
Penicillamine is a well-known heavy metal chelator, classically used in the treatment of Wilson disease, rheumatoid arthritis, and cystinuria. From a dermatologic standpoint, penicillamine was found to be useful in the treatment of systemic sclerosis. The successful therapeutic uses of
P G Conaghan et al.
Current opinion in rheumatology, 8(3), 176-182 (1996-05-01)
The class of agents known as disease-modifying antirheumatic drugs remains the predominant treatment for rheumatoid arthritis. Methotrexate has again demonstrated efficacy in long-term studies, and more reports on its pharmacokinetics and possible mechanism of action have been published. Renal impairment
Mosarrat J Qureshi et al.
The Cochrane database of systematic reviews, 9(9), CD001073-CD001073 (2013-09-05)
The rate of retinopathy of prematurity (ROP) in moderately premature infants has decreased dramatically with improved care in the neonatal intensive care unit. A low rate of this disorder was unexpectedly observed among infants treated with intravenous D-penicillamine to prevent
Laura Atzori et al.
Dermatology online journal, 17(4), 3-3 (2011-05-10)
Long term D-penicillamine (DPA) therapy to treat Wilson disease can induce elastosis perforans serpiginosa (EPS), a very rare degenerative skin disease characterized by a transepidermal elimination of elastic fiber aggregates. The iatrogenous disease depends on DPA capacity to chelate copper
C U Manzini et al.
Clinical rheumatology, 31(1), 183-187 (2011-10-13)
Eosinophilic fasciitis (EF) is a rare disease characterized by symmetrical thickness and hardening of the skin, especially localized to forearms and thorax, with eosinophilia. Corticosteroids represent the first-line therapy, even if some patients are scarcely responsive and/or may develop important
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