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Key Documents

B0490000

Benzarone

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

(2-Ethylbenzofuran-3-yl)(4-hydroxyphenyl)methanone, NSC 82134

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About This Item

Fórmula empírica (notación de Hill):
C17H14O3
Número de CAS:
1477-19-6
Peso molecular:
266.29
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

benzarone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

InChI key

RFRXIWQYSOIBDI-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Benzarone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Certificados de análisis (COA)

Lot/Batch Number

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W Voelter et al.
Journal of chromatography, 290, 1-12 (1984-05-04)
Using 2-ethyl-3-(4- hydroxybenzoyl )benzofuran ( EHBB ) as an example, biotransformation in rabbits and rats and by rat hepatocyte suspensions was studied by high-performance liquid chromatography (HPLC) and mass spectrometry. The biotransformation of N-alkyl-substituted piperidines by rat hepatocytes gives valuable
[On the site of action of benzarone and some other agents influencing the intracellular concentration of cyclic nucleotides].
L O Zwillenberg et al.
Arzneimittel-Forschung, 32(9), 1114-1120 (1982-01-01)
Subfulminant hepatitis requiring liver transplantation after benzarone administration.
M Gehenot et al.
Journal of hepatology, 20(6), 842-842 (1994-06-01)
H Iven et al.
Cancer chemotherapy and pharmacology, 21(4), 337-342 (1988-01-01)
In anesthetized rabbits, continuous infusion of methotrexate (MTX; 30 micrograms kg-1 min-1) established steady-state plasma concentrations for MTX and the metabolite 7-hydroxymethotrexate (7-OH-MTX) within 40 min. Fifty percent of the infused dose was eliminated unchanged by the kidneys and the
S G Wood et al.
Xenobiotica; the fate of foreign compounds in biological systems, 17(7), 881-896 (1987-07-01)
1. The metabolic fate of 14C-benzarone in the rat and dog has been compared to that in human subjects. An oral dose was well-absorbed in all three species. However, the 14C excretion patterns differed: humans (100 mg) excreted means of
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