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48915-U

Sigma-Aldrich

ProClin™ 300

ProClin™ preservative for use in IVD manufacturing, pkg of 2.0 L, CMIT/MIT 3 %

Sinónimos:

3% solution of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-Methyl-4-isothiazolin-3-one

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.21
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

300

form

liquid

shelf life

3 yr

contains

Alkyl Carboxylate

composition

CMIT/MIT, 3%

packaging

pkg of 2.0 L

parameter

<45 °C operating temperature

color

colorless to light yellow

matrix

Modified glycol

operating pH range

2.5-8.5

pH

4.1 (100 g/L)

bp

189 °C

mp

-40 °C

solubility

water: soluble

density

1.03 g/cm3

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Application

ProClin™ preservatives are immediately microstatic upon contact with microbial organisms as a result of their ability to quickly penetrate cell membranes and inhibit specific enzymes crucial to cellular respiration. Multiple specific sites of ProClin™ toxicity prevent microorganisms from developing high levels of resistance, making ProClin™ highly efficient even over extended storage periods of your IVD components.

Legal Information

ProClin is a trademark of LANXESS Corp.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada′s Pest Management Regulatory Agency, Turkey′s Biocidal Products Regulation, Korea′s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

244.4 °F - closed cup

flash_point_c

118 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
MKCX1276
MKCX1277
MKCV6710
MKCW1837
MKCW3712

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James P Higham et al.
PloS one, 6(7), e22398-e22398 (2011-07-30)
Nutritional status is a critical element of many aspects of animal ecology, but has proven difficult to measure non-invasively in studies of free-ranging animals. Urinary C-peptide of insulin (UCP), a small polypeptide cleaved in an equimolar ratio from proinsulin when

Questions

1–7 of 7 Questions  

  1. Would adding an antibody containing Proclin 300 to cell cultures pose a risk of toxicity to the cells?

    1 answer

    1. There isn't any data regarding the minimum concentration of Proclin 300 for use in cell culture. The active ingredients only represent between 3.0 to 3.6% of the total volume of the ProClin 300 as packaged in the bottle. For final use, the active ingredients represent between 7.5 ppm to 15 ppm, which is a combination of the CMIT and MIT active ingredients. A dilution of 0.025% to 0.05% is recommended for biocidal effectiveness. Given the recommendation above, the usage of 5% is very high.

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  2. What is the density of ProClin 300?

    1 answer

    1. The density of ProClin 300 is reported as 8.59 pounds per gallon. The specific gravity at 22°C is reported as 1.03 g/mL.

      Helpful?

  3. What are the active ingredients in ProClin 300?

    1 answer

    1. ProClin 300 contains two active ingredients: 5-Chloro-2-methyl-4-isothiazolin-3-one (CMIT, CAS RN 26172-55-4) and 2-Methyl-4-isothiazolin-3-one (MIT, CAS RN 2682-20-4).

      Helpful?

  4. What is the concentration of active ingredients in ProClin 300?

    1 answer

    1. ProClin 300 contains a total of 3% active ingredient.

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  5. When would I choose to use ProClin 300?

    1 answer

    1. ProClin 300 is best used with production runs of standards, controls, and large volume buffers and solutions.  The product is quite viscous and difficult to work with when trying to measure small volumes.

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  6. What is the matrix of the ProClin 300?

    1 answer

    1. ProClin 300 is a viscous solution containing 93-95 % Modified glycol and 2-3 % Alkyl carboxylate.

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  7. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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