PF033
Fas Ligand, Human, Recombinant
Fas Ligand, Human, Recombinant, consists of amino acids 103-281 fused at the N-terminus to a tag-linker peptide. Binds to human, rat, and mouse Fas.
Sinónimos:
CD95L, CD178
About This Item
Productos recomendados
recombinant
expressed in HEK 293 cells
Quality Level
assay
≥95% (SDS-PAGE)
form
lyophilized
potency
50 ng/mL ED50 (A20 cells)
does not contain
preservative
species reactivity
human, mouse, rat
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
impurities
<0.1 EU/μg Endotoxin (EU/μg purified protein)
shipped in
wet ice
storage temp.
−20°C
General description
Fas/APO1/CD95 (37-42 kDa), a member of the Tumor Necrosis Factor/Nerve Growth Factor (TNF/NGF) receptor family, is an apoptosis-signaling surface receptor known to trigger apoptotic cell death. Homology exists between the Fas and TNF receptors including a region called the "death domain" which is required to propagate the apoptotic signal. The signal activates a family of cysteine proteases, or caspases, which systematically lead to cell destruction. Genetic defects in the Fas system have been shown to lead to autoimmune disorders while increased activity or deregulation contributes to the pathology of diseases such as AIDS.
Packaging
Warning
Physical form
Reconstitution
Other Notes
Golstein, P. et al. 1995. Cell81, 185.
Katsikis, P. et al. 1995. J. Exp. Med.181, 2029.
Nagata, S. et al. 1995. Science267, 1449.
Thompson, C., 1995. Science267, 1456.
Watanabe-Fukunaga, R. et al. 1992. Nature356, 314.
Legal Information
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
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