ABN465

Anti-PICALM Antibody

from rabbit, purified by affinity chromatography

• Sinónimos: Phosphatidylinositol-binding clathrin assembly protein, LAP, CALM, CLTH, Clathrin assembly lymphoid myeloid leukemia protein
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• purificado por: affinity chromatography
• reactividad de especies: mouse
• reactividad de especies (predicha por homología): human (immunogen homology)
• técnicas: western blot: suitable
• Nº de acceso UniProt: Q13492
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PICALM(8301)

Descripción

Descripción general

Phosphatidylinositol-binding clathrin assembly protein (PICALM), also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area as a component of the coated pit internalization machinery. PICALM fusion proteins have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia, and chromosomal aberrations are found in diffuse histiocytic lymphomas. PICALM is also expressed in neuronal synapses where it facilitates the endocytosis of VAMP2. PICALM variants are associated with Alzheimer′s disease and are thought to be involved in the endocytosis and recycling of the amyloid protein precursor (APP).

Especificidad

This antibody can recognize all isoforms of PICALM.

Inmunógeno

KLH-conjugated linear peptide corresponding to human PICALM.

Aplicación

Anti-PICALM Antibody is a highly specific rabbit polyclonal antibody, that targets Phosphatidylinositol-binding clathrin assembly protein & has been tested in western blotting.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Calidad

Evaluated by Western Blotting in EL4 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected PICALM in 15 µg of EL4 cell lysate.

Descripción de destino

~62 kDa and ~71 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 5 isoforms between ~60 kDa and ~71 kDa

Forma física

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
EL4 cell lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable