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Merck
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Documentos clave

5.08510

Sigma-Aldrich

ZD 7288

Sinónimos:

ZD 7288, 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyrimidiniumchloride, Zeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288

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About This Item

Fórmula empírica (notación de Hill):
C15H21ClN4
Número de CAS:
133059-99-1
Peso molecular:
292.81
MDL number:
MFCD29919955
UNSPSC Code:
12352200
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 100 mM

storage temp.

2-8°C

SMILES string

Cl.[n]1([c](cc(nc1C)N(CC)c2ccccc2)=NC)C

InChI

1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H

InChI key

DUWKUHWHTPRMAP-UHFFFAOYSA-N

General description

ZD7288 is a potent HCN blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na+ currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.

Biochem/physiol Actions

Primary Target
HCN channel

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pleasenote that the molecular weight for this compound is batch-specific due tovariable water content.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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N C Harris et al.
Journal of neurophysiology, 74(6), 2366-2378 (1995-12-01)
1. The effects of the novel bradycardic agent 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride (ZD 7288) (Zeneca) were investigated on the hyperpolarization-activated cationic current (Ih) in guinea pig substantia nigra pars compacta neurons in vitro, using a single-microelectrode current-clamp/voltage-clamp technique. 2. Under current-clamp
Xing Wu et al.
Channels (Austin, Tex.), 6(6), 438-442 (2012-09-20)
ZD7288 has been widely used as a tool in the study of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels), and to test the relationships between HCN channels and heart and brain function. ZD7288 is widely considered a selective blocker of HCN

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