5.08506

Gabapentin

• Sinónimos: Gabapentin, L-type Voltage Gated Ca2+ Channel Blocke, Gabapentin
• Fórmula empírica (notación de Hill): C₉H₁₇NO₂
• Número de CAS: 60142-96-3
• Peso molecular: 171.24
• Número MDL: MFCD00865286
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Nivel de calidad: 100
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: water: 100 mM
• temp. de almacenamiento: 2-8°C
• cadena SMILES: [N+H3]CC1(CCCCC1)CC(=O)[O-]
• InChI: 1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
• Clave InChI: UGJMXCAKCUNAIE-UHFFFAOYSA-N

Descripción

Descripción general

A water soluble GABA analog originally developed to treat epilepsy and neuropathic pain but is not believed to act on the same brain receptors. Gabapentin interacts with voltage-gated calcium channels in cortical neurons. It binds to the α2δ subunit (1 and 2) and has been found to reduce calcium currents after chronic but not acute application via an effect on trafficking of voltage-dependent calcium channels in the central nervous system.

Acciones bioquímicas o fisiológicas

Primary Target
α2δ subunit of L-type voltage gated Ca2+ channels

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Eroglu, C. et al. 2009. Cell.139, 380.
Hendrich, J. et al. 2008. Proc. Natl. Acad. Sci. USA105, 3628.
Davies, A. et al. 2007. Trends Pharmacol. Sci.28, 220.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable