5.05816

Xanomeline Oxalate

• Sinónimos: Xanomeline Oxalate, 3-(hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole, Muscarinic Acetylcholine Receptor (mAChR) Agonist, Xanomeline
• Fórmula empírica (notación de Hill): C₁₄H₂₃N₃OS · xC₂H₂O₄
• Número de CAS: 141064-23-5
• Peso molecular: 281.42 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 10 mM; ethanol: 25 mM
• storage temp.: 2-8°C
• InChI: 1S/C14H23N3OS.C2H2O4/c1-3-4-5-6-10-18-14-13(15-19-16-14)12-8-7-9-17(2)11-12;3-1(4)2(5)6/h8H,3-7,9-11H2,1-2H3;(H,3,4)(H,5,6)
• InChI key: ZJOUESNWCLASJP-UHFFFAOYSA-N

Descripción

General description

An agonist selective for muscarinic acetylcholine receptor (mAChR) subtype M1 (EC₅₀ = 0.3, 5, 42, 52 and 92.5 nM at M₁, M₃, M₅, M₄ and M₂ receptors respectively). An antipsychotic agent. Used in improving cognitive deficits and behavioral disturbances in Alzheimer′s disease and schizophrenia.

Warning

Toxicity: Standard Handling (A)

Other Notes

Wang, D., et al., 2011. Biochem. Biophys. Res. Commun.410, 229.
Si, W., et al., 2010. Neurosci. Lett.473, 115.
Stanhope, et al., 2001. J. Exp. Pharmacol. Ther.299, 782.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable