475886

N^G-Monomethyl-L-arginine, Monoacetate Salt

Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of NOS.

• Sinónimos: N^G-Monomethyl-L-arginine, Monoacetate Salt, N ^ω-Me-L-Arg, N ^G-Me-L-Arg, AcOH, L-NMMA, N^ω-Me-L-Arg, N^G-Me-L-Arg, AcOH, L-NMMA
• Fórmula empírica (notación de Hill): C₇H₁₆N₄O₂ · xC₂H₄O₂
• Número de CAS: 53308-83-1
• Peso molecular: 188.23 (free base basis)
• Número MDL: MFCD00069311
• Código UNSPSC: 12352209
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥99% (HPLC); ≥99% (TLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; desiccated (hygroscopic)
• color: white
• solubilidad: water: 50 mg/mL; methanol: soluble
• Condiciones de envío: ambient
• temp. de almacenamiento: 10-30°C
• cadena SMILES: [N+H2]=C(NCCC[C@H](N)C(=O)O)NC.[O-]C(=O)C
• InChI: 1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1
• Clave InChI: IKPNWIGTWUZCKM-JEDNCBNOSA-N

Descripción

Descripción general

Cell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of nitric oxide synthase (K_i = 700 nM for eNOS; K_i = 3.9 µM for iNOS; K_i = 650 nM for nNOS). Inhibits histamine- and acetylcholine-induced relaxation (K_i = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.

L-Arginine analog that acts as a cell-permeable, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) (K_i = 650 nM for nNOS; K_i = 700 nM for eNOS; K_i = 3.9 µM for iNOS). Inhibits histamine- and acetylcholine-induced relaxation (K_i = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.

Acciones bioquímicas o fisiológicas

Cell permeable: yes

Primary Target
eNOS

Product does not compete with ATP.

Reversible: no

Target K_i: 700 nM for eNOS; 3.9 µM for iNOS; 650 nM for nNOS

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.

Otras notas

Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys.320, 170.
O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA88, 4651.
Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun.158, 177.
Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA85, 8664.
Hibbs, J.B., et al. 1987. Science237, 473.
Palmer, R.M.J., et al. 1987. Nature327, 524.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable