182540-M

Aromatase Inhibitor I

The Aromatase Inhibitor I, also referenced under CAS 331684-05-0, controls the biological activity of Aromatase.

• Sinónimos: Aromatase Inhibitor I, 4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone
• Fórmula empírica (notación de Hill): C₁₇H₁₁N₃O₄
• Número de CAS: 331684-05-0
• Peso molecular: 321.29
• Número MDL: MFCD00064211
• Código UNSPSC: 12352200

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥95% (HPLC)
• Formulario: solid
• fabricante / nombre comercial: Calbiochem^®
• condiciones de almacenamiento: OK to freeze; protect from light
• color: white
• solubilidad: DMSO: 25 mg/mL
• temp. de almacenamiento: −20°C

Descripción

Descripción general

A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC₅₀ = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17α-hydroxylase.

A potent, selective, nonsteroidal, competitive inhibitor of aromatase (P450arom) (IC₅₀ = 40 nM for human aromatase) Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit human 17α-hydroxylase (P450 17) (4% inhibition at 2.5 µM).

Acciones bioquímicas o fisiológicas

Primary Target
P450 arom.

Target IC₅₀: 40 nM against P450arom

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Otras notas

Recanatini, M., et al. 2001. J. Med. Chem.44, 672.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable