1.03669

Glicina

granulated, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• Sinónimos: Glicocola, Ácido aminoacético, Ácido aminoetanoico
• Fórmula lineal: NH₂CH₂COOH
• Número de CAS: 56-40-6
• Peso molecular: 75.07
• Beilstein: 635782
• Número MDL: MFCD00008131
• Código UNSPSC: 12352209
• Número índice de la CE: 200-272-2

Propiedades

• Agency: BP; ChP; JP; Ph. Eur.; USP
• Nivel de calidad: 500
• presión de vapor: 0.0000171 Pa ( 25 °C)
• descripción: granulated EMPROVE^® EXPERT Ph.Eur.,BP,JP,USP
• Línea del producto: EMPROVE^® EXPERT
• Ensayo: 99.0-101.0% (calculated on dried substance, perchloric acid titration)
• Formulario: granular
• técnicas: inhibition assay: suitable
• pH: 5.9-6.4 (20 °C, 50 g/L in H₂O)
• pKa (25 °C): (1) 2.35, (2) 9.60; 2.35
• mp: 240 °C (dec.) (lit.)
• densidad: 1.161 g/cm³ at 20 °C
• aplicaciones: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• temp. de almacenamiento: 2-30°C
• cadena SMILES: NCC(O)=O
• InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• Clave InChI: DHMQDGOQFOQNFH-UHFFFAOYSA-N

Descripción

Descripción general

Standard bulk materials often show a tendency for caking, clumping and dust formation which results in laborious weighing processes and manual de-caking processes with a negative impact on manufacturing efficiency. Due to its granulated form, granulated glycine is free-flowing and easy to handle. Its greatly reduced caking behavior facilitates processability, speeds up manufacturing processes and increases operator safety.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Aplicación

Glycine in general is widely used in the biopharma industry as a stabilizer, tonicity modifier, buffer and precipitating agent. It is also used as an emollient, emulsifying agent and solubilizer in solid and semi-solid formulations.
Due to its low microbial and endotoxin limits, Glycine granulated Emprove^® Expert is especially suitable for high-risk applications.

Acciones bioquímicas o fisiológicas

Neurotransmisor inhibidor de la médula espinal, regulador alostérico de los receptores NMDA.

Información legal

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable