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Merck
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Key Documents

05-780

Sigma-Aldrich

Anti-Akt3/PKBγ Antibody, clone GMA104

clone GMA104, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

GMA104, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_005465

UniProt accession no.

Q9Y243

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... AKT3(10000)

Specificity

Predicted to cross-react with mouse and rat based on sequence homology.
RhoA

Immunogen

peptide corresponding to amino acids 119-131 (CSPTSQIDNIGEE) of human Akt3/PKBγ

Application

Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling
This Anti-Akt3/PKBγ Antibody, clone GMA104 is validated for use in IP, WB for the detection of Akt3/PKBγ.

Quality

routinely evaluated by immunoblot on RIPA lysates from Jurkat or HL-60 cells

Target description

~60kDa

Physical form

Buffered solution containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.
Format: Purified
Protein A purified

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Rebekka Geißert et al.
Cell communication and signaling : CCS, 22(1), 85-85 (2024-01-31)
K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins and downstream signaling pathways. Here, we
Conrad P Hodgkinson et al.
Biochemistry, 41(32), 10351-10359 (2002-08-07)
Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine
Aroa Soriano et al.
Oncotarget, 7(8), 9271-9287 (2016-01-30)
Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or function, activating the DNA damage response (DDR). In cancer, this process is frequently altered
The Akt isoforms are present at distinct subcellular locations.
Santi, SA; Lee, H
American Journal of Physiology. Cell Physiology null

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