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O-025

Supelco

Oxcarbazepine solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C15H12N2O2
Número de CAS:
28721-07-5
Peso molecular:
252.27
Número CE:
200-835-2
Código UNSPSC:
41116107
NACRES:
NA.24
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grado

certified reference material

Nivel de calidad

300

Formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

1.0 mg/mL in acetonitrile

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

clinical testing

Formato

single component solution

temp. de almacenamiento

−20°C

cadena SMILES

NC(=O)N1c2ccccc2CC(=O)c3ccccc13

InChI

1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19)

Clave InChI

CTRLABGOLIVAIY-UHFFFAOYSA-N

Información sobre el gen

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

Descripción general

Oxcarbazepine, marketed under the trade name Trileptal®, is an anticonvulsant developed and prescribed for treatment of epilepsy. In recent years, Oxcarbazepine has shown efficacy in treatment of mood disorders. This certified solution standard is suitable as starting material for the preparation of calibrators and controls in oxcarbazepine testing by GC/MS or LC-MS/MS.

Aplicación


  • Quantitative analysis for therapeutic monitoring: Oxcarbazepine solution is utilized in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the quantitative analysis of drug levels in patients undergoing epilepsy treatment. This approach aids in therapeutic drug monitoring, ensuring drug efficacy and safety (Johnson-Davis and Thomas, 2024).

  • Advanced detection techniques: Research integrates Raman spectroscopy and convolutional neural networks for the detection of antiepileptic drug concentrations, including Oxcarbazepine. This technology enhances the precision of drug measurement, vital for managing and controlling seizures in neurological disorders (Fu et al., 2023).

  • Environmental impact studies: Studies on the degradation of Oxcarbazepine by bromate in water under sunlight irradiation provide critical data on the environmental behavior of this pharmaceutical. Understanding its environmental breakdown helps in assessing the ecological impact and designing better waste management strategies (Sun et al., 2023).


Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Trileptal is a registered trademark of Novartis Corporation

Pictogramas

FlameExclamation mark
GHS02,GHS07

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

35.6 °F - closed cup

Punto de inflamabilidad (°C)

2 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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Régis Bouquié et al.
Therapie, 65(1), 61-65 (2010-03-09)
Oxcarbazepine is an analogue of carbamazepine, used for the treatment of partial seizure with or without secondary generalization. The two forms R and S of the mono-hydroxylated derivatives (MHD) are responsible for most of the anti-convulsant activity and it is
Ekaterine Popova et al.
Expert review of neurotherapeutics, 7(6), 617-626 (2007-06-15)
Oxcarbazepine is an antiepileptic drug that has been approved by the US FDA and is indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and children aged over 4 years. The aim of
Barbara R Sommer et al.
Expert opinion on drug safety, 6(2), 133-145 (2007-03-21)
Few controlled studies are available to guide the clinician in treating potentially assaultive elderly individuals with psychiatric disorders. Safety concerns limit the use of benzodiazepines and antipsychotic medications in the elderly individual, making anticonvulsants an attractive alternative. This paper reviews
A Vasudev et al.
The Cochrane database of systematic reviews, (1)(1), CD005171-CD005171 (2008-02-07)
Some studies have suggested that oxcarbazepine has a role in preventing episode recurrence in bipolar affective disorder. This review attempted to investigate the existing evidence from randomised controlled trials for its use in the maintenance treatment of this illness. To
Gaetano Zaccara et al.
Seizure, 22(7), 528-536 (2013-04-30)
Analysis of overall tolerability and neurological adverse effects (AEs) of eslicarbazepine acetate (ESL), lacosamide (LCM) and oxcarbazepine (OXC) from double-blind, placebo-controlled trials. Indirect comparisons of patients withdrawing because of AEs, and the incidence of some vestibulocerebellar AEs between these three
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