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M-152

Supelco

Mitragynine solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C23H30N2O4
Número de CAS:
4098-40-2
Peso molecular:
398.50
EC Number:
200-659-6
MDL number:
MFCD09838906
UNSPSC Code:
41116107
PubChem Substance ID:
329817883
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

O=C(OC)/C([C@H]1C[C@@](N(C[C@H]1CC)CC2)([H])C3=C2C(C(OC)=CC=C4)=C4N3)=C/OC

InChI

1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16+,19+/m1/s1

InChI key

LELBFTMXCIIKKX-QVRQZEMUSA-N

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General description

Mitragynine, commonly known as Kratom, is the most abundant alkaloid in the plant Mitragynine speciosa. Sold over the internet as herbal plant extracts, Kratom is noted for its psychoactive, stimulant, and sedative effects depending on the dosage level. According to DEA′s Drugs and Chemicals of Concern page, mitragynine use can lead to addiction with adverse effects ranging from anorexia and weight loss to hallucinations and delusion.

Application



  • Pharmacokinetic Interaction of Kratom and Cannabidiol: A study analyzed the pharmacokinetic interactions between mitragynine and cannabidiol in male rats, providing critical insights for co-administration of these compounds (Berthold et al., 2024).


  • Enhancement of Low-Dose Doxorubicin Cytotoxicity by Kratom Extracts: Research investigated whether kratom extracts enhance the cytotoxic effects of low-dose doxorubicin against lung cancer cells, suggesting a potential use of mitragynine in cancer therapy (Bayu et al., 2024).


  • Extraction and Detection of Mitragynine: A technique using high-performance liquid chromatography for the extraction and detection of mitragynine from Kratom leaves was developed, enhancing the accuracy and efficiency of mitragynine isolation for research purposes (Ng and Ha, 2024).


  • Amelioration of Mitragynine Withdrawal Symptoms: A study explored the potential of an epigenetic mechanism to ameliorate withdrawal behavior and cognitive impairments caused by mitragynine, contributing to better management strategies for opioid withdrawal symptoms (Yunusa et al., 2024).


  • Imaging Mass Spectrometry Analysis of Mitragynine: Research utilized MALDI imaging mass spectrometry to study the distribution of Mitragyna speciosa alkaloids, including mitragynine, in dosed rat brain tissue, advancing the understanding of its biochemical behavior (Liang et al., 2024).


Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Anika A Philipp et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(15-16), 1049-1055 (2011-04-01)
Mitragyna speciosa (Kratom in Thai), native in Southeast Asia, is increasingly misused as a herbal drug of abuse. During metabolism studies on the Kratom alkaloids mitragynine, its diastereomers speciogynine and speciociliatine as well as paynantheine in rats and humans, further
Juraithip Wungsintaweekul et al.
Biotechnology letters, 34(10), 1945-1950 (2012-06-21)
Mitragynine is a pharmacologically-active terpenoid indole alkaloid found in Mitragyna speciosa leaves. Treatment with methyl jasmonate (10 μM) for 24 h and yeast extract (0.1 mg/ml) for 12 h were the optimum conditions of elicitation of mitragynine accumulation in a
Suhanya Parthasarathy et al.
Forensic science international, 226(1-3), 183-187 (2013-02-07)
Mitragyna speciosa, a native plant of Thailand and Malaysia known as 'ketum', is a plant of considerable interest. It exhibits strong antinociceptive effect and yet, acts like a psychostimulant. Due to the affordability and its ease of availability, the abuse
Isabel P Kerschgens et al.
Chemical communications (Cambridge, England), 48(100), 12243-12245 (2012-11-15)
The pharmacologically interesting indole alkaloids (-)-mitragynine, (+)-paynantheine and (+)-speciogynine were synthesised in nine steps from 4-methoxytryptamine by a route featuring (i) an enantioselective thiourea-catalysed Pictet-Spengler reaction, providing the tetrahydro-β-carboline ring and (ii) a Pd-catalysed Tsuji-Trost allylic alkylation, closing the D-ring.
Friedrich G Kapp et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 7(3), 227-231 (2011-04-30)
Kratom (Mitragyna speciosa) is a common medical plant in Thailand and is known to contain mitragynine as the main alkaloid. According to an increase in published reports and calls at German poison control centers, it has been used more frequently
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