We describe a simple derivatization method to determine aldehydes. This method is based on derivatization with D-cysteine and consecutive liquid chromatography-tandem mass spectrometry (LC-MS/MS). The optimum derivatization conditions of aldehydes with D-cysteine were 10 min at 50°C and pH 7.0.
Journal of medicinal chemistry, 49(17), 5282-5290 (2006-08-18)
Calpain is a cytosolic cysteine endopeptidase that has been implicated in a number of disorders including cancer. We have synthesized and studied the mu-calpain inhibitory activity and cytotoxicity of peptidyl aldehydes and peptidyl alpha-ketoamides with N-substituted D-proline or L-thiaproline residues
Rapid photoassisted access to N,O,S-polyheterocycles with benzoazocine and hydroquinoline cores: intramolecular cycloadditions of photogenerated azaxylylenes.
Olga A Mukhina et al.
Angewandte Chemie (International ed. in English), 50(40), 9423-9428 (2011-09-02)
European journal of medicinal chemistry, 44(10), 3903-3908 (2009-05-09)
Nine 2-arylthiazolidine-4-carboxylic acid derivatives and nine 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives were synthesized to screen for their antibacterial activities. Compounds 5, 14-18 were first reported. Their chemical structures were clearly determined by (1)H NMR, (13)C NMR, ESI mass spectra and elemental analyses
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