QBD10910

m-dPEG^®₃₇-NHS ester

>95% (HPLC)

• Sinónimos: m-PEG₃₇-NHS ester, mPEG-NHS ester, mPEG₁₅₀₀-NHS ester, mPEG₃₇-NHS ester
• Fórmula empírica (notación de Hill): C₈₀H₁₅₅NO₄₁
• Peso molecular: 1787.07
• Número MDL: MFCD21363217
• Código UNSPSC: 12352108
• NACRES: NA.22

Propiedades

• Ensayo: >95% (HPLC)
• Formulario: solid or viscous liquid
• idoneidad de la reacción: reaction type: Pegylations
• arquitectura del polímero: shape: linear; functionality: monofunctional
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: N1(C(=O)CCC1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
• InChI: 1S/C80H155NO41/c1-85-6-7-87-10-11-89-14-15-91-18-19-93-22-23-95-26-27-97-30-31-99-34-35-101-38-39-103-42-43-105-46-47-107-50-51-109-54-55-111-58-59-113-62-63-115-66-67-117-70-71-119-74-75-121-77-76-120-73-72-118-69-68-116-65-64-114-61-60-112-57-56-110-53-
• Clave InChI: ACOTVRARFKQDPT-UHFFFAOYSA-N

Descripción

Características y beneficios

m-dPEG₃₇-NHS ester is a methyl-terminated, single molecular weight, discrete chain length polyethylene glycol (dPEG) spacer. The carboxylic acid moiety on the end of the molecule opposite the methyl cap is activated with N-hydroxysuccinimide (NHS) for facile reaction with free amines. The dPEG spacer is 112 atoms (133.9 Å) long, a monodisperse equivalent of a polymeric PEG₁₅₀₀. m-dPEG₃₇-NHS ester can be used to modify silica shelled quantum dots to make them water-soluble. Also, it has been employed to improve the pharmacokinetic (PK) and biodistribution (BD) properties of an antibody. Carbon nanotubes and inorganic nanoparticles with amine-functionalized surfaces could also be modified to passivate the surface and make it hydrophilic. Overall, proteins and other biomolecules conjugated to this product will have higher water solubility, reduced or eliminated antigenicity, and improved PK and BD properties.

Información legal

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable