Saltar al contenido
Merck

900606

Sigma-Aldrich

Fmoc-Trp-BODIPY

≥95%

Sinónimos:

Trp-BODIPY

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Fórmula empírica (notación de Hill):
C45H39BF2N4O4
Peso molecular:
748.62
UNSPSC Code:
12352111
NACRES:
NA.22

Quality Level

assay

≥95%

form

powder

functional group

Fmoc

Application

This compound is an Fmoc-labeled amino acid of tryptophan attached to a BODIPY dye through a spacer-free C-C linkage that can be used in solid phase peptide synthesis (SPPS). Research presented in Mendive-Tapia et al. tested the incorporation of the fluorescent amino acid into an anti-fungal peptide with two tryptophans by replacing either one or both of the residues. The three peptides showed enhanced fluorescence with increasing hydrophobicity of the environment. The peptides also maintained binding to Aspergillus fumigatus and could be detected by fluorescence imaging. That same publication showed that a cyclic version of the peptide containing a single fluorescent amino acid was more resistant to proteolysis than the linear peptide and still useful for imaging. The amino acid can be incorporated during standard conditions for SPPS and can also tolerate mildly acidic conditions of 1% trifluoroacetic acid allowing use of acid-labile solid supports. This amino acid should enable fluorescence detection of peptides for use in a variety of applications.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Spacer-free BODIPY fluorogens in antimicrobial peptides for direct imaging of fungal infection in human tissue.
Tapia ML, et al.
Nature Communications, 7, 10940-10940 (2016)

Contenido relacionado

Optical imaging has revolutionized our understanding of how biological systems behave at a molecular level. In our group we develop Dynamic Activatable Fluorophores (DYNAFLUORS) as chemical probes to image molecular events associated to inflammation and cancer.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico