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207713

Sigma-Aldrich

1,3-Di-o-tolylguanidine

99%

Sinónimos:

DTG

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About This Item

Fórmula lineal:
(CH3C6H4NH)2C(=NH)
Número de CAS:
97-39-2
Peso molecular:
239.32
Número CE:
202-577-6
Número MDL:
MFCD00008513
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
24852467
NACRES:
NA.22
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nivel de calidad

100

Ensayo

99%

Formulario

solid

mp

176-178 °C (lit.)

solubilidad

water: soluble 70 mg/mL at 20 °C

grupo funcional

amine

cadena SMILES

Cc1ccccc1NC(=N)Nc2ccccc2C

InChI

1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

Clave InChI

OPNUROKCUBTKLF-UHFFFAOYSA-N

Información sobre el gen

human ... EBP(10682)

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Descripción general

1,3-Di-o-tolylguanidine is a selective σ-receptor agonist[1]. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice[2].

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCW7506
MKCV7802
MKCW1600
MKCW1599
MKCW8211

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F P Monnet et al.
The Journal of pharmacology and experimental therapeutics, 307(2), 705-712 (2003-09-17)
Intracellular calcium concentration ([Ca2+]i) plays a major role in neuronal excitability, especially that triggered by the N-methyl-d-aspartate (NMDA)-sensitive glutamatergic receptor. We have previously shown that sigma1 receptor agonists potentiate NMDA receptor-mediated neuronal activity in the hippocampus and recruit Ca2+-dependent second
Thibault Mesplède et al.
AIDS (London, England), 29(6), 659-665 (2015-04-08)
In treatment-naive HIV-positive individuals, the integrase strand-transfer inhibitor dolutegravir (DTG) has not been associated with emergent drug-resistance mutations, neither against this drug nor against other antiretroviral drugs that were used in combination with it. This is in contrast to all
Zur Mira Azizah Nor Haiza Lah et al.
Journal of pharmaceutical and biomedical analysis, 174, 608-617 (2019-07-03)
A facile electrochemical sandwich immunosensor for the detection of a breast cancer biomarker, the human epidermal growth factor receptor 2 (HER2), was designed, using lead sulfide quantum dots-conjugated secondary HER2 antibody (Ab2-PbS QDs) as a label. Using Ab2-PbS QDs in
Mona Ebadi et al.
Scientific reports, 10(1), 21521-21521 (2020-12-11)
The use of nanocarriers composed of polyethylene glycol- and polyvinyl alcohol-coated vesicles encapsulating active molecules in place of conventional chemotherapy drugs can reduce many of the chemotherapy-associated challenges because of the increased drug concentration at the diseased area in the
Moya A Hay et al.
Chemical science, 10(25), 6354-6361 (2019-07-26)
The magnetic properties of 3d monometallic complexes can be tuned through geometric control, owing to their synthetic accessibility and relative structural simplicity. Monodentate ligands offer great potential for fine-tuning the coordination environment to engineer both the axial and rhombic zero-field
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Questions

1–3 of 3 Questions  

  1. What is the nature of the biological activity of Product 207713, 1,3-di-o-tolylguanidine?

    1 answer

    1. 1,3-Di-o-tolylguanidine is known to be a selective ligand for the sigma site in the mammalian central nervous system. Behavioral changes, such as hypothermia, reduced pain behavior, circling behavior, and decreased locomotor activity in mice and/or rats were observed after intraperitoneal, subcutaneous, intravenous and/or intranigral injection.

      Helpful?

  2. What is the solubility of Product 207713, 1,3-di-o-tolylguanidine?

    1 answer

    1. 1,3-Di-o-tolylguanidine is soluble in water at 70 micrograms per mL at ambient temperature.

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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