177466
4-Methylcyclohexylamine, mixture of cis and trans
97%
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About This Item
Fórmula lineal:
CH3C6H10NH2
Número de CAS:
Peso molecular:
113.20
Número CE:
Número MDL:
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
NACRES:
NA.22
Productos recomendados
Nivel de calidad
Ensayo
97%
Formulario
liquid
índice de refracción
n20/D 1.4531 (lit.)
bp
151-154 °C (lit.)
densidad
0.855 g/mL at 25 °C (lit.)
cadena SMILES
CC1CCC(N)CC1
InChI
1S/C7H15N/c1-6-2-4-7(8)5-3-6/h6-7H,2-5,8H2,1H3
Clave InChI
KSMVBYPXNKCPAJ-UHFFFAOYSA-N
Descripción general
Trans-4-methylcyclohexylamine is a spermidine synthase inhibitor.
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Flam. Liq. 3 - Skin Corr. 1B
Código de clase de almacenamiento
3 - Flammable liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
80.6 °F - closed cup
Punto de inflamabilidad (°C)
27 °C - closed cup
Equipo de protección personal
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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Masaki Kobayashi et al.
Biological & pharmaceutical bulletin, 29(5), 863-867 (2006-05-03)
A close relationship between rat liver regeneration and the concentration ratio of spermidine to spermine (spd:spm) was demonstrated by the oral administration of trans-4-methylcyclohexylamine (MCHA), a specific inhibitor of putrescine aminopropyltransferase. A decrease in recovery rate of remnant liver with
Keijiro Samejima et al.
Biological & pharmaceutical bulletin, 30(10), 1943-1946 (2007-10-06)
A sensitive method for the determination of polyamines in mammalian cells was described using electrospray ionization and time-of-flight mass spectrometer. This method was 50-fold more sensitive than the previous method using ionspray ionization and quadrupole mass spectrometer. The method employed
Masatake Sano et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 80-83 (2006-08-26)
An assay for spermidine synthase (SPDS) activity in rat liver has been developed using micellar electrokinetic chromatography (MEKC) with laser-induced fluorescence (LIF) detection to enable the discovery of SPDS inhibitors. The assay was established by estimating the amount of spermidine
TachaZi Plym Forshell et al.
Cancer prevention research (Philadelphia, Pa.), 3(2), 140-147 (2010-01-28)
The oncogenic transcription factor c-Myc (Myc) is frequently overexpressed in human cancers. Myc is known to induce or repress a large set of genes involved in cell growth and proliferation, explaining the selection for mutations in cancer that deregulate Myc
Keijiro Samejima
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 126(8), 529-542 (2006-08-02)
This review describes my work in the field of polyamine research for the last 35 years. My research started with developing the improved synthesis of decarboxylated S-adenosylmethionine and then moved to the purification of spermidine synthase from rat prostate. I
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