47864

Nicotinic acid

analytical standard

• Synonym(s): 3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B₃
• Empirical Formula (Hill Notation): C₆H₅NO₂
• CAS Number: 59-67-6
• Molecular Weight: 123.11
• Beilstein: 109591
• EC Number: 200-441-0
• MDL number: MFCD00006391
• UNSPSC Code: 12164500
• PubChem Substance ID: 24871534

Properties

• grade: analytical standard
• Quality Level: 100
• CofA: current certificate can be downloaded
• feature: standard type water soluble vitamin
• packaging: ampule of 1000 mg
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 236-239 °C (lit.)
• density: 1.473 g/cm³ at 25 °C
• application(s): pharmaceutical (small molecule); vitamins, nutraceuticals, and natural products
• format: neat
• storage temp.: 2-30°C
• SMILES string: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

Description

General description

Nicotinic acid acts as an antilipolytic drug in adipose tissue, and is commonly used for hyperlipoproteinaemia and pellagra.

Nicotinic acid is a water soluble, vitamin belonging to B complex group of vitamins, which can be used as a broad spectrum lipid lowering drug. Its mode of action basically involves the inhibition of the hormone-sensitive triglyceride lipase and thereby, decreasing the lipolysis in adipose tissue.

Application

Nicotinic acid may be used as an analytical reference standard for the quantification of the analyte in tablet dosage forms using reversed-phase high-performance liquid chromatography technique.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Recommended products

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Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): 379.4 °F - closed cup
• Flash Point(C): 193 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves