SML0443

SU-5402

≥98% (HPLC), powder, FGFR inhibitor

• Synonym(s): 3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid, PF-02969207, PNU-0290908
• Empirical Formula (Hill Notation): C₁₇H₁₆N₂O₃
• CAS Number: 215543-92-3
• Molecular Weight: 296.32
• MDL number: MFCD08235144
• UNSPSC Code: 51111800
• PubChem Substance ID: 329824725
• NACRES: NA.77

Properties

• product name: SU-5402, ≥98% (HPLC)
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: light yellow to dark orange
• solubility: DMSO: 10 mg/mL (clear solution)
• storage temp.: −20°C
• SMILES string: Cc1c[nH]c(\C=C2/C(=O)Nc3ccccc23)c1CCC(O)=O
• InChI: 1S/C17H16N2O3/c1-10-9-18-15(11(10)6-7-16(20)21)8-13-12-4-2-3-5-14(12)19-17(13)22/h2-5,8-9,18H,6-7H2,1H3,(H,19,22)(H,20,21)/b13-8-
• InChI key: JNDVEAXZWJIOKB-JYRVWZFOSA-N

Description

Application

SU5402 has been used as a fibroblast growth factor receptor inhibitor:

• in cell signalling experiments to stimulate cells for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay
• to study its effect on the expression of osteogenic markers and expression of osteoprotegerin and RANKL (runt-related transcription factor(RUNX)-2
• to prepare a stock solution with DMSO (Dimethyl superoxide) for cell culture medium and also to co-treat embryos
• to study its effect on osteogenic markers.

Biochem/physiol Actions

SU-5402 has inhibitory effect on the action of tyrosine kinases. It competitively binds to the ATP-binding site on the fibroblast growth factor receptor (FGFR).

SU-5402 is a FGFR antagonist and angiogenesis inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable