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Key Documents

SCP0102

Sigma-Aldrich

Caspase Substrate

≥95% (HPLC), lyophilized

Synonym(s):

Ac-AEVD-pNA

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About This Item

Empirical Formula (Hill Notation):
C25H34N6O11
Molecular Weight:
594.57
UNSPSC Code:
12352202
NACRES:
NA.32

product name

Caspase Substrate,

Assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

Amino Acid Sequence

Acetyl-Ala-Glu-Val-Asp-p-Nitro-Anilide

Biochem/physiol Actions

The modified tetrapeptide Ac-AEVD-pNA, is a chromogenic substrate for caspase-10.

Certificates of Analysis (COA)

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M Fujino et al.
International immunopharmacology, 1(11), 2011-2021 (2001-10-19)
FTY720, a novel immunosuppressive drug originally derived from a metabolite from Isaria sinclairii, is known to induce apoptosis in lymphocytes. In this study, we investigated the involvement of caspases and mitochondria in FTY720-mediated apoptosis using Jurkat cells, a human T
S Kojio et al.
FEMS immunology and medical microbiology, 29(4), 275-281 (2000-12-19)
Caspase proteolytic activities, such as caspase-3, -2 and -6, of THP-1 human monocytic cells were markedly increased in a time- and dose-dependent manner by treatment with purified Shiga toxin 1 (Stx1) or Stx2. Caspase-3 activation was strictly correlated with internucleosomal
Vladislava Juric et al.
Molecular and cellular biology, 29(12), 3266-3279 (2009-04-15)
Although Fas ligand (FasL) is primarily expressed by lymphoid cells, its receptor Fas (CD95/Apo-1) is broadly expressed in numerous nonlymphoid tissues and can mediate apoptosis of parenchymal cells upon injury and infiltration of inflammatory cells. Here we show that CCN1

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