Z-DNA binding protein 1 (ZBP1), also known as interferon (IFN) γ-inducible gene, is a cytoplasmic DNA sensor. It belongs to the family of Z-DNA binding proteins. ZBP1 is majorly expressed in the small intestine and lymphatic tissues. The gene is located on human chromosome 20q13.3.
Immunogen
a 18 amino acid peptide from near the carboxy-terminus of human ZBP1.
Application
Anti-ZBP1 antibody produced in rabbit has been used for western blotting.
Biochem/physiol Actions
Z-DNA binding protein 1 (ZBP1) plays a major role in DNA mediated innate immune responses. It enhances nuclear factor k-light-chain-enhancer of activated B cells (NFκB) activation and proinflammatory cytokine production.
Linkage
The action of this antibody can be blocked using blocking peptide SBP4401.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
BioMed research international, 2016, 9872138-9872138 (2017-01-21)
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