55460

Hydroxylamine hydrochloride

puriss. p.a., ACS reagent, ≥99.0% (RT)

• Synonym(s): Hydroxylammonium chloride
• Linear Formula: NH₂OH · HCl
• CAS Number: 5470-11-1
• Molecular Weight: 69.49
• Beilstein: 3539763
• EC Number: 226-798-2
• MDL number: MFCD00051089
• UNSPSC Code: 12352300
• PubChem Substance ID: 329758115
• NACRES: NB.24

Properties

• grade: ACS reagent; puriss. p.a.
• Quality Level: 300
• vapor pressure: 0.001 hPa ( 50 °C)
• Assay: ≥99.0% (RT)
• form: powder or crystals
• technique(s): inhibition assay: suitable
• ign. residue: ≤0.05% (as SO₄)
• pH: 2.5-3.5 (25 °C, 50 mg/mL in H₂O)
• mp: 155-157 °C (dec.) (lit.)
• density: 1.67 g/mL at 25 °C (lit.)
• anion traces: sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg; heavy metals: ≤5 ppm (by ICP)
• SMILES string: Cl.NO
• InChI: 1S/ClH.H3NO/c;1-2/h1H;2H,1H2
• InChI key: WTDHULULXKLSOZ-UHFFFAOYSA-N

Description

General description

Hydroxylamine hydrochloride (Hydroxylammonium chloride) is the hydrochloride salt of hydroxylamine. It participates in the synthesis of 1,2,4-oxadiazoles.

Application

• Mass Spectrometry-Based Atlas of Extracellular Matrix Proteins across 25 Mouse Organs.: This study utilized hydroxylamine hydrochloride in mass spectrometry to analyze the extracellular matrix proteins in various mouse organs, offering insights into tissue-specific protein compositions (McCabe et al., 2023).



• Analysis of extracellular metabolome by HS-SPME/GC-MS: Optimization and application in a pilot study to evaluate galactosamine-induced hepatotoxicity.: Hydroxylamine hydrochloride was employed in HS-SPME/GC-MS to optimize the analysis of extracellular metabolites, crucial for assessing hepatotoxic effects (Araújo et al., 2018).



• Improved production and processing of ⁸⁹Zr using a solution target.: This research enhanced the production process of zirconium-89 with hydroxylamine hydrochloride, improving efficiency and yield for medical imaging applications (Pandey et al., 2016).



• Evaluation of the physicochemical properties and the biocompatibility of polyethylene glycol-conjugated gold nanoparticles: A formulation strategy for siRNA delivery.: The study used hydroxylamine hydrochloride to modify gold nanoparticles, improving their biocompatibility and effectiveness in siRNA delivery systems (Rahme et al., 2015).



• Preparation and photocatalytic performance of Fe (III)-amidoximated PAN fiber complex for oxidative degradation of azo dye under visible light irradiation.: Hydroxylamine hydrochloride was used in the synthesis of Fe(III)-amidoximated PAN fibers, enhancing their photocatalytic degradation properties for environmental applications (Dong et al., 2010).

Biochem/physiol Actions

MAO inhibitor; inhibits platelet aggregation.

Safety Information

• Pictograms: GHS08,GHS05,GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H290,H302 + H312,H315,H317,H319,H351,H373,H410
• Precautionary Statements: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Carc. 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral
• Target Organs: spleen
• Storage Class Code: 4.1A - Other explosive hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable