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936448

Sigma-Aldrich

Fmoc-Gly-Gly-Gly-OH

≥95%

Synonym(s):

2-[2-[2-([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)acetamido]acetamido]acetic acid, 2-[[2-[[2-(9H-Fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]acetic acid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycylglycine, Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycylglycyl-, Glycine, N-[N-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl]glycyl]-

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About This Item

Empirical Formula (Hill Notation):
C21H21N3O6
CAS Number:
Molecular Weight:
411.41
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.22

Quality Level

Assay

≥95%

form

powder or crystals

color

white to off-white

storage temp.

2-8°C

SMILES string

O=C(OCC1C=2C=CC=CC2C=3C=CC=CC31)NCC(=O)NCC(=O)NCC(=O)O

InChI

InChI= 1S/C21H21N3O6/c25-18(23-11-20(27)28)9-22-19(26)10-24-21(29)30-12-17-15-7-3-1-5-13(15)14-6-2-4-8-16(14)17/h1-8,17H,9-12H2,(H,22,26)(H,23,25)(H,24,29)(H,27,28)

Application

Fmoc-Gly-Gly-Gly-OH is a lysosomally cleavable linker used in construction of antibody-drug conjugates (ADC & Bioconjugation).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Strategies and challenges for the next generation of antibody-drug conjugates
Beck A, et al.
Nature Reviews Drug Discovery, 16, 315-337 (2017)

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