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Sigma-Aldrich

3-Chloro-L-tyrosine

97%

Synonym(s):

(2S)-2-Amino-3-(3-chloro-4-hydroxyphenyl)propanoic acid, Monochlorotyrosine

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About This Item

Linear Formula:
4-(HO)C6H3(Cl)CH2CH(NH2)CO2H
CAS Number:
7423-93-0
Molecular Weight:
215.63
EC Number:
231-050-3
MDL number:
MFCD00045865
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24873634
NACRES:
NA.22

Assay

97%

optical activity

[α]24/D −2°, c = 1 in 1 M HCl

reaction suitability

reaction type: solution phase peptide synthesis

mp

249 °C (lit.)

application(s)

peptide synthesis

SMILES string

N[C@@H](Cc1ccc(O)c(Cl)c1)C(O)=O

InChI

1S/C9H10ClNO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

InChI key

ACWBBAGYTKWBCD-ZETCQYMHSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Mariusz G Fleszar et al.
Molecules (Basel, Switzerland), 25(21) (2020-11-11)
Quantification with satisfactory specificity and sensitivity of free 3-Nitro-l-tyrosine (3-NT), 3-Chloro-l-tyrosine (3-CT), and 3-Bromo-l-tyrosine (3-BT) in biological samples as potential inflammation, oxidative stress, and cancer biomarkers is analytically challenging. We aimed at developing a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based method
Cédric Delporte et al.
Talanta, 99, 603-609 (2012-09-13)
A high degree of uremia is common in patients with end-stage renal disease and has been linked to the development of chronic inflammation and cardiovascular diseases. In conditions where transplantation is not possible, uremia can be reduced by hemodialysis although
Joseph I Kang et al.
Chemical research in toxicology, 21(5), 1028-1038 (2008-05-03)
While the last 30 years chronicles an extensive effort to understand the damage to DNA caused by reactive oxygen species (ROS), little research has examined the chemical damage to the histone proteins found in chromatin. Hypochlorous acid (HOCl), the primary
Jihan Talib et al.
Free radical biology & medicine, 53(1), 20-29 (2012-05-23)
Smokers have an elevated risk of atherosclerosis but the origin of this elevated risk is incompletely defined, though increasing evidence supports a role for the oxidant-generating enzyme myeloperoxidase (MPO). In previous studies we have demonstrated that smokers have elevated levels
Laetitia Mouls et al.
Proteomics, 9(6), 1617-1631 (2009-03-03)
Protein oxidation is thought to contribute to a number of inflammatory diseases, hence the development of sensitive and specific analytical techniques to detect oxidative PTMs (oxPTMs) in biological samples is highly desirable. Precursor ion scanning for fragment ions of oxidized
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