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15369

Sigma-Aldrich

N-Boc-ethylenediamine

≥98.0% (NT)

Synonym(s):

N-Boc-1,2-diaminoethane, tert-Butyl N-(2-aminoethyl)carbamate

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About This Item

Linear Formula:
(CH3)3COCONHCH2CH2NH2
CAS Number:
Molecular Weight:
160.21
Beilstein:
1932330
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.22
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Quality Level

Assay

≥98.0% (NT)

reaction suitability

reagent type: cross-linking reagent

refractive index

n20/D 1.458 (lit.)
n20/D 1.458

bp

72-80 °C/0.1 mmHg (lit.)

density

1.012 g/mL at 20 °C (lit.)

functional group

Boc
amine

SMILES string

NCCNC(OC(C)(C)C)=O

InChI

1S/C7H16N2O2/c1-7(2,3)11-6(10)9-5-4-8/h4-5,8H2,1-3H3,(H,9,10)

InChI key

AOCSUUGBCMTKJH-UHFFFAOYSA-N

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Application

  • Facile synthesis of new N-(aminocycloalkylene) amino acid compounds: Describes the use of N-Boc-ethylenediamine in the preparation of benzyl 2-{[2-(Boc-amino)ethyl]amino}acetate (G Matulevičiūtė et al., 2023).
  • Synthesis of a new tripod BODIPY dye: Reports on the chemical synthesis involving N-Boc-ethylenediamine for creating a BODIPY dye (H Wang et al., 2022).
  • Single‐Entity Electrocatalysis: Discusses the application of N-Boc-ethylenediamine in modifying Co3O4 nanoparticles used in electrocatalysis (T Quast et al., 2021).

Other Notes

Mono-protected derivative of ethylenediamine, preparation of pharmacologically active analogues; [1][2][3] introduction of an ethylenediamine spacer.[1][4][5]

Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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Synthesis of N,N-dilactitol ethylenediamine: a versatile spacer for attachment of residualizing labels to protein.
M M Dowd et al.
Analytical biochemistry, 205(2), 369-371 (1992-09-01)
Hao Li et al.
Investigative ophthalmology & visual science, 58(12), 5142-5150 (2017-10-08)
Intravitreal injection of antiangiogenic agents is becoming a standard treatment for neovascular retinal diseases. Sustained release of therapeutics by injecting colloidal carriers is a promising approach to reduce the injection frequency, which reduces treatment burdens and the risk of complications
Qi Zhang et al.
Journal of biophotonics, 11(6), e201700339-e201700339 (2018-01-18)
Targeting cyclooxygenase-2 (COX-2) for molecular imaging is an attractive approach applicable for its overexpression in inflammation and many malignancies. Herein, for monitoring COX-2, we synthesize a specific COX-2 probe celecoxib-MPA probe (CMP), based on celecoxib and a water-soluble near-infrared dye
G. Kada et al.
Biochimica et Biophysica Acta, 1427, 33-33 (1998)
Deborah Sultan et al.
Small (Weinheim an der Bergstrasse, Germany), 14(30), e1703115-e1703115 (2018-07-03)
Focused ultrasound (FUS) technology is reported to enhance the delivery of 64 Cu-integrated ultrasmall gold nanoclusters (64 Cu-AuNCs) across the blood-brain barrier (BBB) as measured by positron emission tomography (PET). To better define the optimal physical properties for brain delivery

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    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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