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USP

Tranexamic acid

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

trans-4-(Aminomethyl)cyclohexanecarboxylic acid, AMCA, AMCHA, HAKU, TAMCHA, Tranexamic acid

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About This Item

Linear Formula:
H2NCH2C6H10CO2H
CAS Number:
1197-18-8
Molecular Weight:
157.21
Beilstein:
2207452
MDL number:
MFCD00001466
UNSPSC Code:
41116107
PubChem Substance ID:
329751362
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

tranexamic acid

manufacturer/tradename

USP

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

NC[C@H]1CC[C@@H](CC1)C(O)=O

InChI

1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7-

InChI key

GYDJEQRTZSCIOI-LJGSYFOKSA-N

Gene Information

human ... PLG(5340)

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Tranexamic acid USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Tranexamic Acid Tablets
  • Tranexamic Acid Injection

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tranexamic acid in trauma: how should we use it?
Lena M Napolitano et al.
The journal of trauma and acute care surgery, 74(6), 1575-1586 (2013-05-23)
Evelyn S Lundin et al.
Acta obstetricia et gynecologica Scandinavica, 93(4), 335-344 (2014-01-17)
To determine whether single-dose tranexamic acid given intravenously immediately before surgery for presumed advanced ovarian cancer reduces perioperative blood loss and blood transfusions. A randomized double-blind, placebo-controlled multicenter study. Two university hospitals and two central hospitals in the southeast health
Joseph G Martin et al.
The Journal of arthroplasty, 29(5), 889-894 (2013-11-19)
Major blood loss is a known potential complication in total hip and total knee arthroplasty. We conducted a prospective, stratified, randomized, double-blind, placebo-controlled trial that evaluated 100 patients undergoing total knee or total hip arthroplasty to evaluate the effect on
K Ker et al.
The British journal of surgery, 100(10), 1271-1279 (2013-07-11)
Tranexamic acid (TXA) reduces blood transfusion in surgery but the extent of the reduction in blood loss and how it relates to the dose of TXA is unclear. A systematic review of randomized trials was performed. Data were extracted on
Anthony E Pusateri et al.
Shock (Augusta, Ga.), 39(2), 121-126 (2012-12-12)
A recent large civilian randomized controlled trial on the use of tranexamic acid (TXA) for trauma reported important survival benefits. Subsequently, successful use of TXA for combat casualties in Afghanistan was also reported. As a result of these promising studies
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