SRP5220
KAT8 (2-467), GST tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
FLJ14040, KAT8, MOF, MYST1, hMOF
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About This Item
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biological source
human
recombinant
expressed in baculovirus infected Sf9 cells
Assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
mol wt
~83 kDa
NCBI accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... KAT8(84148)
General description
Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). MYST1 has a chromodomain that is involved in protein-protein interactions and targeting transcriptional regulators to the chromatin.
Biochem/physiol Actions
Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) was originally isolated as a human immunodeficiency virus-1 (HIV-1) TAT-interactive protein, which plays important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. MYST1 is also involved in ataxia-telangiectasia mutated (ATM) function. It acetylates histone 4-lysine 16 (H4K16). The protein is a modulator of embryonic stem cells and an epigenetic regulator. It has been associated with gastric carcinoma.
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells.
Mu X
Cellular Reprogramming, 17(4), 259-267 (2015)
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Gupta A
Cell Reports, 8(1), 177-189 (2014)
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L
International Journal of Oncology, 46(6), 2535-2545 (2015)
Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture.
Thomas T
Molecular and Cellular Biology, 28(16), 5093-5105 (2008)
Arun Gupta et al.
Molecular and cellular biology, 25(12), 5292-5305 (2005-06-01)
We have determined that hMOF, the human ortholog of the Drosophila MOF gene (males absent on the first), encoding a protein with histone acetyltransferase activity, interacts with the ATM (ataxia-telangiectasia-mutated) protein. Cellular exposure to ionizing radiation (IR) enhances hMOF-dependent acetylation
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