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SAB4504269

Sigma-Aldrich

Anti-phospho-TGF β Receptor II (pSer225/250) antibody produced in rabbit

affinity isolated antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 64 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunohistochemistry: 1:50-1:100

NCBI accession no.

P37173

UniProt accession no.

P37173

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer225/pSer250)

Gene Information

human ... TGFBR2(7048)

General description

Transforming growth factor β receptor 2 (TGFBR2) is a serine/threonine protein kinase, that belongs to the TGFβ receptor subfamily. It is located on human chromosome 3p24.

Immunogen

The antiserum was produced against synthesized peptide derived from human TGF beta Receptor II around the phosphorylation site of Ser225/250.

Immunogen Range: 191-240

Biochem/physiol Actions

Transforming growth factor β receptor 2 (TGFBR2) plays an important role in signal transduction resulting in mitogenic responses. Mutation in TGFBR2 result in Loeys-Dietz syndrome and Marfan syndrome.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Heterozygous TGFBR2 mutations in Marfan syndrome
Mizuguchi T, et al.
Nature Genetics, 36(8), 855-860 (2004)
TGFBR2-dependent alterations of exosomal cargo and functions in DNA mismatch repair-deficient HCT116 colorectal cancer cells
Fricke F, et al.
Cell communication and signaling : CCS, 15, 14-14 (2017)
Arthrogryposis as neonatal presentation of Loeys-Dietz syndrome due to a novel TGFBR2 mutation
Valenzuela I, et al.
European Journal of Medical Genetics, 60(6), 303-307 (2017)
Tianyu Li et al.
Molecular medicine reports, 17(3), 4057-4061 (2017-12-30)
Keloid formation is characterized by hyperproliferation of secretory and responsive keloid fibroblasts (KFs) and overproduction of extracellular matrix (ECM). Eukaryotic translation initiation factor 3 subunit A (eIF3a) one of the core subunits of the translation initiation complex, eIF3, has previously been reported
Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing
Zimmermann MT, et al.
PLoS ONE, 12(2), e0170822-e0170822 (2017)

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