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Key Documents

SAB4300738

Sigma-Aldrich

Anti-Collagen IV antibody produced in rabbit

affinity isolated antibody

Synonym(s):

ALPHA-1 CHAIN ARRESTEN, COL4A1 NC1 domain, COLLAGEN OF BASEMENT MEMBRANE, alpha 1 type IV collagen preproprotein, collagen IV alpha-1 polypeptide

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

160 kDa

species reactivity

mouse, human

concentration

1.0 mg/mL

technique(s)

immunohistochemistry: 1:50-1:100
western blot: 1:500-1:3000 (Cell Lysate)

isotype

IgG

accession no.

NP_001836.2

UniProt accession no.

P02462

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL4A1(1282)

General description

COL4A1 (collagen type IV α 1 chain) belongs to the collagen family. It has an N-terminal 7S domain, a C-terminal globular domain (NC1), and the central triple helical part with short interruptions of the Gly-X-Y repeats. It is an important constituent of type IV collagen in the basement membrane. The COL4A1 gene is located on human chromosome 13q34.

Specificity

The antibody detects endogenous levels of total Collagen IV protein.

Immunogen

Synthesized peptide derived from human Collagen IV.

Application

Collagen Type IV from human cell culture has been used in immunofluorescent analysis.

Biochem/physiol Actions

COL4A1 (collagen type IV α 1 chain) related disorder is associated with pulmonary complication. Mutations in COL4A1 result in familial porencephaly, infantile hemiplegia, cerebral small vessel disease (CSVD) and hemorrhagic stroke.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Collagens?structure, function, and biosynthesis
Gelse K, et al.
Advanced Drug Delivery Reviews, 55 (2003)
Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100?nm Particles
Sakurai Y, et al.
Molecular Therapy, 24(12), 2090-2099 (2016)
Association of COL4A1 gene polymorphisms with cerebral palsy in a Chinese Han population.
Bi D, et al.
Clinical Genetics, 90(2), 149-155 (2016)
Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome.
Alamowitch S, et al.
Neurology, 73(22), 1873-1882 (2009)
Yu Sakurai et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 24(12), 2090-2099 (2016-09-17)
A number of nano drug delivery systems have recently been developed for cancer treatment, most of which are based on the enhanced permeability and retention effect. The advantages of the enhanced permeability and retention effect can be attributed to immature
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