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Key Documents

I1252

Sigma-Aldrich

DL-Isocitric acid trisodium salt hydrate

≥93%

Synonym(s):

threo-DsLs-Isocitric acid trisodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):
C6H5Na3O7 · xH2O
CAS Number:
Molecular Weight:
258.07 (anhydrous basis)
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.25

Assay

≥93%

SMILES string

O.[Na+].[Na+].[Na+].OC(C(CC([O-])=O)C([O-])=O)C([O-])=O

InChI

1S/C6H8O7.3Na.H2O/c7-3(8)1-2(5(10)11)4(9)6(12)13;;;;/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13);;;;1H2/q;3*+1;/p-3

InChI key

BPEHKAXIRZOKIS-UHFFFAOYSA-K

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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An-Ping Lin et al.
Biochemistry, 50(38), 8241-8250 (2011-08-25)
Yeast NAD(+)-specific isocitrate dehydrogenase is an allosterically regulated octameric enzyme composed of four heterodimers of a catalytic IDH2 subunit and a regulatory IDH1 subunit. Despite structural predictions that the enzyme would contain eight isocitrate binding sites, four NAD(+) binding sites
Ming-dong Wang et al.
Chinese medical journal, 124(17), 2611-2615 (2011-11-02)
Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of α-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway. However, given that
Metabolism, gliomas, and IDH1.
Jan Smeitink
The New England journal of medicine, 362(12), 1144-1145 (2010-03-26)
Alexander B Taylor et al.
The Journal of biological chemistry, 283(16), 10872-10880 (2008-02-08)
Mitochondrial NAD(+)-specific isocitrate dehydrogenases (IDHs) are key regulators of flux through biosynthetic and oxidative pathways in response to cellular energy levels. Here we present the first structures of a eukaryotic member of this enzyme family, the allosteric, hetero-octameric, NAD(+)-specific IDH
Ho-Ju Fan-Chiang et al.
Journal of AOAC International, 93(3), 956-965 (2010-07-16)
Sugar and nonvolatile acid analyses were conducted on 52 samples of blackberries (Rubus spp), the objective being to develop a compositional database for evaluating authenticity and quality. Brix ranged from 6.88 to 16.83, with a mean of 10.82. Titratable acidity

Protocols

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

Chromatograms

application for HPLC

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