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92897

Sigma-Aldrich

Poly(ethylene glycol)

BioUltra, 10,000

Synonym(s):

Polyethylene glycol, Polyethylene oxide, Polyoxyethylene, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
MDL number:
UNSPSC Code:
12352104
PubChem Substance ID:
NACRES:
NA.26

Quality Level

product line

BioUltra

form

solid

mol wt

Mr 8500-11500

impurities

insoluble matter:, passes filter test
≤0.001% peroxides (as H2O2):

pH

5.5-7.0 (25 °C, 50 mg/mL in H2O)

mp

62-65 °C

solubility

H2O: 50 mg/mL at 25 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

50 mg/mL in H2O

UV absorption

λ: 260 nm Amax: 0.09
λ: 280 nm Amax: 0.03

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

Poly(ethylene glycol) (PEG), a linear polyether of ethylene glycol (ethane-1,2-diol), is soluble in water, benzene, ethanol, acetonitrile, and dichloromethane. However, it is insoluble in diethyl ether and hexane. This non-ionic polymer can exist in the monomer and aqueous phases.

Application

Poly(ethylene glycol) has been used:

  • in cryopreservation of cell-laden multi-assay platforms (MAPs)
  • as a macromolecular crowder to study its effects on fluorescein isothiocyanate (FITC)-conjugated type-I collagen
  • as a model surfactant in surfactant formulations to evaluate the interfacial aggregation of antibody formulations in response to interfacial stress

Biochem/physiol Actions

Poly(ethylene glycol) (PEG) is used in several applications including medicine. This polymer occurs as a preservative and is used in biomedical applications like drug delivery systems, biosensing, and tissue engineering. PEG is also used in cosmetic ointments and creams. It is used as a binding and dispersing agent in chemical and other industries.

Features and Benefits

  • Environment friendly
  • Biocompatible
  • Unique solvent solution

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Aadithya Kannan et al.
Journal of colloid and interface science, 550, 128-138 (2019-05-06)
Monoclonal antibodies (mAbs) are therapeutic proteins used in the treatment of many diseases due to their specificity in binding targets. Aggregation of these molecules is a major challenge in their formulation development. MAbs spontaneously adsorb onto air-solution interfaces and experience
Polymers and polymeric hybrids for targeted drug delivery
Islam R and Fang J
Journal of Separation Science, 303-322 (2022)
Polymers for 3D bioprinting
Beata K
Journal of Separation Science (2022)
Application of compatibilized polymer blends in biomedical fields
Zarrintaj P, et al.
Journal of Separation Science, 511-537 (2020)
Adam S Zeiger et al.
PloS one, 7(5), e37904-e37904 (2012-06-01)
Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture. Here, we induced macromolecular crowding in vitro by using synthetic macromolecular globules of nm-scale

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