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A3669

Supelco

Acebutolol hydrochloride

analytical standard

Synonym(s):

N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide

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About This Item

Empirical Formula (Hill Notation):
C18H28N2O4 · HCl
CAS Number:
34381-68-5
Molecular Weight:
372.89
EC Number:
251-980-3
MDL number:
MFCD00078860
UNSPSC Code:
41116107
PubChem Substance ID:
329770842
NACRES:
NA.24

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

Cl.CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(C)=O

InChI

1S/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H

InChI key

KTUFKADDDORSSI-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

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General description

Acebutolol hydrochloride is a β-adrenergic receptor blocker. It is used in the treatment of hypertension, cardiac arrhythmias and angina pectoris.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBL5415V
BCBL5415
056K1622V
056K1622
056K1622

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2013 Nurse's Drug Handbook (2012)
The effect of acebutolol on the cerebral circulation of man.
Hares P, et al.
British Journal of Clinical Pharmacology, 4(3), 373-375 (1977)
Alexandros Klavdios Steriotis et al.
The American journal of cardiology, 109(7), 1015-1019 (2012-01-10)
The aim of this study was to assess exercise test results and efficacy of therapy with a β blocker (acebutolol) in ryanodine receptor type 2 (RyR2) mutation carriers with documented ventricular arrhythmias (VAs) and long-term follow-up. Twenty RyR2 mutation carriers
Hironobu Umezawa et al.
Biomedical chromatography : BMC, 22(7), 702-711 (2008-03-05)
A detailed procedure for the analysis of four beta-blockers, acebutolol, labetalol, metoprolol and propranolol, in human plasma by high-performance liquid chromatography (LC)-tandem mass spectrometry (MS-MS) using an MSpak GF column, which enables direct injection of crude plasma samples, is presented.
Iu M Alekseeva et al.
Kardiologiia, 47(12), 24-34 (2008-02-12)
Beta-blocking agents (BB) decrease mortality particularly sudden in post-myocardial infarction patients and in patients with chronic heart failure that is closely related to heart rate (HR) lowering at rest. The hypothesis exists that BB decrease mortality due to increase of
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Chromatograms

application for HPLC

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