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Difenoconazol

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

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About This Item

Empirical Formula (Hill Notation):
C19H17Cl2N3O3
CAS Number:
Molecular Weight:
406.26
Beilstein:
9073356
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
TraceCERT®

Quality Level

100
300

product line

TraceCERT®

form

solid

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

storage temp.

2-8°C

SMILES string

CC1COC(Cn2cncn2)(O1)c3ccc(Oc4ccc(Cl)cc4)cc3Cl

InChI

1S/C19H17Cl2N3O3/c1-13-9-25-19(27-13,10-24-12-22-11-23-24)17-7-6-16(8-18(17)21)26-15-4-2-14(20)3-5-15/h2-8,11-13H,9-10H2,1H3

InChI key

BQYJATMQXGBDHF-UHFFFAOYSA-N

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General description

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ. Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate. Download your certificate at: http://www.sigma-aldrich.com.

Difenoconazole is a broad-spectrum systematic triazole fungicide that controls foliar, seed, and soil-borne diseases caused by ascomycetes, basidiomycetes, and deuteromycetes infecting tobacco, cereals, fruits, vegetables, ornamentals, and other crops. Difenoconazole inhibits fungal cytochrome P450 sterol 14α-demethylase (cyp51) activity and blocks ergosterol biosynthesis, thus hindering the chitin synthesis of the fungal cell, resulting in cell death. It has strong internal absorption and is characterized by high efficiency, broad-spectrum application, low toxicity, and low required dosage.

Difenoconazole has to be monitored in the Multiannual Control Programme for Pesticides Residues (MACP), run within the EU and EFTA in/on products of plant origin.

Difenoconazole is approved for use in European Union as per Regulation (EC) No 1107/2009. Maximum residue levels (MRLs) for Difenoconazole have been set according to Regulation (EU) No 2019/552 for products of animal origin from 0.005 to 0.2 mg/kg and plants from 0.05 to 20 mg/kg.

Application

It is intended to be used as a certified reference material (CRM) for calibration in chromatography and other analytical techniques. Difenoconazole CRM may also find its use as described below:
  • Study the developmental effects of difenoconazole and its mechanism on zebrafish embryos
  • To develop a sample preparation and detection method for the determination of difenoconazole residue in banana fruits, pulp, and peels by GC-ECD
  • Determination of difenoconazole residue in Chinese cabbage and soil using a solid phase extraction (SPE) cleanup and gas chromatography method
  • Determination of difenoconazole residue in tomato paste during home canning using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS)
  • To develop an analytical method for the determination of abamectin and difenoconazole in stingless bee M. scutellaris by LC-MS/MS

Legal Information

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation markEnvironment

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Fernanda Scavassa Ribeiro do Prado et al.
Environmental pollution (Barking, Essex : 1987), 265(Pt B), 114313-114313 (2020-08-19)
Bees are considered as important providers of ecosystem services, acting via pollination process in crops and native plants, and contributing significantly to the maintenance of biodiversity. However, the decrease of bee's population has been observed worldwide and besides other factors
Qun Zheng et al.
Environmental science and pollution research international, 27(13), 15365-15374 (2020-02-23)
The dissipation and terminal residues of difenoconazole in whole bananas and pulp were investigated under field conditions. The residual levels of difenoconazole in various parts of bananas grown in Guangdong, Hainan and Yunnan were determined by a GC-ECD detection method
Cong Guo et al.
Bulletin of environmental contamination and toxicology, 85(4), 427-431 (2010-09-25)
Difenoconazole was a triazole fungicide with proven bio-efficacy which leads to morphological and functional changes in the fungal cell membrane. In this work, field trials were conducted in three apple orchards. Sampling methods were improved in both the terminal residual
Xiyan Mu et al.
Environmental pollution (Barking, Essex : 1987), 212, 18-26 (2016-02-04)
Difenoconazole is a widely used triazole fungicide and has been reported to have negative impacts on zebrafish embryos. To investigate the mechanism of its developmental toxicity, zebrafish embryos were exposed to 0.5 and 2.0 mg/L difenoconazole for 96 h. The morphological and
Cong Guo et al.
Bulletin of environmental contamination and toxicology, 85(4), 427-431 (2010-09-25)
Difenoconazole was a triazole fungicide with proven bio-efficacy which leads to morphological and functional changes in the fungal cell membrane. In this work, field trials were conducted in three apple orchards. Sampling methods were improved in both the terminal residual

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