5.30961

TAZ Activator, IBS008738

• Synonym(s): TAZ Activator, IBS008738, (4-((morpholinomethylene)amino)-1-(p-tolyl)-1H-imidazol-5-yl)(phenyl)methanone, Transcriptional Co-activator with PDZ-binding Motif (TAZ) Activator, WWTR1 Activator
• Empirical Formula (Hill Notation): C₂₂H₂₂N₄O₂
• CAS Number: 385425-03-6
• Molecular Weight: 374.44
• UNSPSC Code: 12352200
• PubChem Substance ID: 6160351
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 50 mg/mL
• storage temp.: −20°C
• SMILES string: CC1=CC=C(C=C1)N2C=NC(=C2C(=O)C3=CC=CC=C3)N=CN4CCOCC4

Description

General description

A benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

A benzoylimidazole derivative that acts as a Transcriptional co-activator with PDZ-binding motif (TAZ) Activator by stabilizing TAZ and increases unphosphorylated TAZ. Up-regulates TAZ-dependent MyoD-dependent gene transcription at 10 µM and competes with myostatin in C2C12 cells. Shown to enhance myogenesis most effectively when applied for the first 24 hours under the differentiation condition. Facilitates muscle repair in cardiotoxin-induced muscle injury and prevents dexamethasone-induced muscle atrophy.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Biochem/physiol Actions

Cell permeable: yes

Reversible: yes

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Yang, Z., et al. 2014. Mol. Cell. Biol.34, 1607.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable