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P9906

Sigma-Aldrich

Poly(ethylene glycol) bis(amine)

average MN 3,400, cross-linking reagent carboxyl reactive, amine

Synonym(s):

Polyethylene glycol, O,O′-Bis(2-aminoethyl)polyethylene glycol, Diaminopolyethylene glycol, PEG-diamine, Polyoxyethylene bis(amine)

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About This Item

Linear Formula:
H2N(CH2CH2O)nCH2CH2NH2
CAS Number:
24991-53-5
MDL number:
MFCD00132004
UNSPSC Code:
12162002
PubChem Substance ID:
24898931
NACRES:
NA.23

product name

Poly(ethylene glycol) bis(amine), average Mn 3400

form

powder

Quality Level

200

mol wt

average Mn 3400

reaction suitability

reagent type: cross-linking reagent
reactivity: carboxyl reactive

Ω-end

amine

α-end

amine

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

InChI

1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

InChI key

IWBOPFCKHIJFMS-UHFFFAOYSA-N

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Application

Poly(ethylene glycol) bis(amine) may be used in the preparation of folic acid-PEG-NH2 conjugate. PEG-bis(amine) has been reported to be used as a component in the making of Au-Fe2O3 NPs based multifunctional nanoprobe for multimodal and ultrasensitive detection of cancer cells.

Preparation Note

Prepared from PEG with an average molecular weight of 3,350

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H315,H317,H318,H334

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Development and characterization of folate targeted nanoparticle drug delivery system
Mittal V, et al.
International Journal of Pharmacy and Biological Sciences, V1(2) (2000)
Jian Liu et al.
Chemical communications (Cambridge, England), 49(43), 4938-4940 (2013-04-23)
A multifunctional nanoprobe, which can be used for dual modal imaging and the detection of cancer cells, has been reported.
Development and characterization of folate targeted nanoparticle drug delivery system
mittal V, et al.
International Journal of Pharmacy and Biological Sciences, V1(2) (2010)
Evaluation of receptor mediated endocytosis on cellular internalization: a comparative study of pegylated nanoparticles and folate anchored pegylated nanoparticles on mda-mb-231 cells
Mahalwar A, et al.,
International Journal of Biological & Pharmaceutical Research null
Cara E Humphrey et al.
Journal of the American Chemical Society, 125(46), 13952-13953 (2003-11-13)
The lipase-catalyzed kinetic resolution of (R/S)-3-phenylbutyric acid 2 using solid-supported cyclohexane-1,3-dione (CHD) 6 is described. In each case the predominant enantiomer observed, after cleavage from the resin, was (R)-(-)-3-phenylbutyric acid (R)-2 (ee > 99%) rather than the expected (S)-enantiomer of
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